Fragen R J, Hanssen E H, Denissen P A, Booij L H, Crul J F
Acta Anaesthesiol Scand. 1983 Apr;27(2):113-6. doi: 10.1111/j.1399-6576.1983.tb01918.x.
The purpose of this study was to evaluate disoprofol as the hypnotic for total intravenous anaesthesia. Sixty women undergoing minor gynaecological surgery participated and were randomly assigned to four groups (N = 15 in each group). Disoprofol, 2 mg/kg was given i.v. to induce anaesthesia after a bolus injection of either fentanyl 1.875 micrograms/kg or alfentanil 18.75 micrograms/kg. Vecuronium, 0.06 mg/kg, was given for muscle relaxation when indicated. One-half of the patients received acute premedication with midazolam, 5 mg i.v. Anaesthesia was maintained with a continuous infusion of disoprofol 150 micrograms/kg/min and either fentanyl 0.125 micrograms/kg/min or alfentanil 1.25 micrograms/kg/min. These drug combinations were compatible and produced good operating conditions. Awakening time was significantly shorter for women who received no premedication and was not affected by the narcotic used. Respiration returned more quickly when fentanyl was the narcotic given and was not affected by premedication. Both hypotension and bradycardia were seen in some patients, but other side effects were infrequent. This total intravenous anaesthesia technique was very well accepted by the patients and the nurses who cared for them in the postoperative period.
本研究的目的是评估丙泊酚作为全静脉麻醉催眠药的效果。60例接受小型妇科手术的女性参与研究，随机分为四组（每组N = 15）。在静脉注射1.875微克/千克芬太尼或18.75微克/千克阿芬太尼推注后，静脉给予2毫克/千克丙泊酚诱导麻醉。必要时给予0.06毫克/千克维库溴铵进行肌肉松弛。一半患者静脉注射5毫克咪达唑仑进行急性术前用药。通过持续输注150微克/千克/分钟丙泊酚以及0.125微克/千克/分钟芬太尼或1.25微克/千克/分钟阿芬太尼维持麻醉。这些药物组合相互兼容，产生了良好的手术条件。未接受术前用药的女性苏醒时间显著缩短，且不受所用麻醉药的影响。当使用芬太尼作为麻醉药时，呼吸恢复更快，且不受术前用药的影响。部分患者出现低血压和心动过缓，但其他副作用较少见。这种全静脉麻醉技术在术后得到了患者和护理他们的护士的高度认可。
