Ledderose H, Rester P, Carlsson P, Peter K
Klinikum Grosshadern, Universität München, Federal Republic of Germany.
Anaesthesia. 1988 Mar;43 Suppl:89-91. doi: 10.1111/j.1365-2044.1988.tb09083.x.
Two anaesthetic procedures that did not include nitrous oxide were compared in a randomised study of 50 patients for tympanoplasty and tympanoscopy: propofol given for induction and maintenance, and thiopentone-isoflurane given for induction and maintenance, respectively. Induction in the first group was with a bolus injection of propofol and the same agent was given for the duration of anaesthesia by continuous intravenous administration. Thiopentone was given until loss of the eyelash reflex and anaesthesia maintained with isoflurane 0.4-2.0%. Analgesia was achieved in both groups by fentanyl given intravenously and by local injection of mepivacaine with ornipressin. The two patient groups were analysed for age, sex and weight as well as for side effects during the induction, maintenance and recovery periods, such as coughing, vomiting, venous pain, spontaneous movements, singultus, headaches, dysrhythmias and psychic disorders possibly due to anaesthesia. Side effects were moderate in both groups. Recovery time was statistically significantly shorter in the propofol group and the patients in this group appeared to be much more aware after recovery than those in the thiopentone-isoflurane group.
在一项针对50例接受鼓室成形术和鼓膜镜检查患者的随机研究中，对两种不包括一氧化二氮的麻醉方法进行了比较：分别采用丙泊酚诱导和维持麻醉，以及硫喷妥钠-异氟烷诱导和维持麻醉。第一组诱导时静脉推注丙泊酚，麻醉期间通过持续静脉给药给予相同药物。给予硫喷妥钠直至睫毛反射消失，并用0.4-2.0%的异氟烷维持麻醉。两组均通过静脉注射芬太尼和局部注射甲哌卡因加去甲肾上腺素实现镇痛。对两组患者的年龄、性别、体重以及诱导期、维持期和恢复期的副作用进行了分析，如咳嗽、呕吐、静脉疼痛、自主运动、呃逆、头痛、心律失常以及可能由麻醉引起的精神障碍。两组的副作用均为中度。丙泊酚组的恢复时间在统计学上显著缩短，且该组患者恢复后似乎比硫喷妥钠-异氟烷组患者更清醒。
