Korttila K, Ostman P, Faure E, Apfelbaum J L, Prunskis J, Ekdawi M, Roizen M F
Department of Anesthesia and Critical Care, University of Chicago, Illinois.
Acta Anaesthesiol Scand. 1990 Jul;34(5):400-3. doi: 10.1111/j.1399-6576.1990.tb03111.x.
A randomized, prospective study was performed to compare recovery characteristics in 41 ASA physical status I-II patients scheduled for ambulatory surgery with either propofol or thiopentone-isoflurane anaesthesia. Particular attention was focused on the recovery time needed to meet discharge criteria. The propofol group received propofol 2 mg.kg-1 for induction followed by propofol infusion (6-9 mg.kg-1.h-1) 1 min after intubation. The thiopentone-isoflurane group received thiopentone 4 mg.kg-1 for induction followed by isoflurane (0.5-2%) 1 min after endotracheal intubation. Other drugs administered during or after anaesthesia were similar between the groups. The propofol group had significantly (P less than 0.05) faster clinical recovery than the isoflurane group with respect to times to response to commands, eye opening, orientation, ability to stand and void, tolerance to oral fluids, "home-readiness", and recovery of perceptual speed. Patients in the propofol group had significantly less (P less than or equal to 0.05) emesis than the patients given isoflurane. We conclude that in patients undergoing ambulatory surgery propofol infusion is preferable to thiopentone-isoflurane anaesthesia, because it may allow faster discharge home.
进行了一项随机前瞻性研究，比较41例拟行门诊手术的ASA身体状况I-II级患者使用丙泊酚或硫喷妥钠-异氟烷麻醉后的恢复特征。特别关注达到出院标准所需的恢复时间。丙泊酚组诱导时给予丙泊酚2mg·kg-1，插管后1分钟开始丙泊酚输注（6-9mg·kg-1·h-1）。硫喷妥钠-异氟烷组诱导时给予硫喷妥钠4mg·kg-1，气管插管后1分钟开始给予异氟烷（0.5-2%）。两组麻醉期间或之后使用的其他药物相似。在对指令的反应时间、睁眼、定向、站立和排尿能力、对口服液体的耐受性、“准备回家”以及感知速度恢复方面，丙泊酚组的临床恢复明显（P<0.05）快于异氟烷组。丙泊酚组患者的呕吐明显少于使用异氟烷的患者（P≤0.05）。我们得出结论，在门诊手术患者中，丙泊酚输注优于硫喷妥钠-异氟烷麻醉，因为它可能使患者更快出院回家。
