Bolme P, Eriksson M, Habte D, Paalzow L
Department of Pediatrics, Huddinge Hospital, Stockholm, Sweden.
Eur J Clin Pharmacol. 1988;33(6):647-9. doi: 10.1007/BF00542504.
Fifty-six malnourished Ethiopian children with tuberculosis classified in four nutritional groups (normal, underweight, marasmus and kwashiorkor), were given streptomycin 20 or 30 mg.kg-1 i.m. The plasma concentration-time data revealed an increased apparent volume of distribution in children with kwashiorkor compared to normals. The total plasma clearance was low and did not differ between the nutritional groups. Thus, the half-life was prolonged only in kwashiorkor. The results could be explained by decreased protein binding in plasma and decreased renal clearance by glomerular filtration.
56名患有结核病的营养不良埃塞俄比亚儿童被分为四个营养组（正常、体重不足、消瘦和夸希奥科病），接受了20或30mg.kg-1的链霉素肌肉注射。血浆浓度-时间数据显示，与正常儿童相比，夸希奥科病儿童的表观分布容积增加。总血浆清除率较低，且在各营养组之间无差异。因此，只有夸希奥科病儿童的半衰期延长。这些结果可以通过血浆中蛋白质结合减少和肾小球滤过导致的肾清除率降低来解释。
