Eriksson M, Bolme P, Habte D, Paalzow L
Departments of Pediatrics, St. Göran's Hospital, Stockholm, Sweden.
Acta Paediatr Scand. 1988 Nov;77(6):890-4. doi: 10.1111/j.1651-2227.1988.tb10774.x.
The plasma concentration of INH and streptomycin was followed in 45 Ethiopian children with tuberculosis. The children were grouped according to their nutritional status as normal, underweight, marasm and kwashiorkor. INH was well absorbed in all nutritional groups to give therapeutically active plasma levels. When terminal half life (t1/2) of INH was calculated for individual patients there were more children in all nutritional groups with t1/2 greater than or equal to 2 hours than less than 2 hours, indicating a slow acetylation of INH. Streptomycin was well absorbed in all nutritional groups and therapeutic levels were obtained with 20 mg/kg i.m. After 30 mg/kg i.m. of streptomycin kwashiorkor children had an increased t1/2 of streptomycin indicating a decreased renal excretion of the drug in kwashiorkor. The clinical follow-up of the children indicated that serious tuberculosis could be successfully treated with INH and streptomycin in the doses used.
对45名患有结核病的埃塞俄比亚儿童的异烟肼和链霉素血浆浓度进行了跟踪监测。这些儿童根据营养状况分为正常、体重不足、消瘦和夸希奥科病组。异烟肼在所有营养组中均能被很好地吸收，从而达到具有治疗活性的血浆水平。当计算个体患者异烟肼的终末半衰期（t1/2）时，所有营养组中t1/2大于或等于2小时的儿童比小于2小时的儿童更多，这表明异烟肼的乙酰化作用缓慢。链霉素在所有营养组中均能被很好地吸收，肌肉注射20mg/kg可达到治疗水平。肌肉注射30mg/kg链霉素后，夸希奥科病儿童链霉素的t1/2增加，表明夸希奥科病儿童药物的肾脏排泄减少。对这些儿童的临床随访表明，使用所采用剂量的异烟肼和链霉素可成功治疗严重结核病。
