Laboratory of Parasitology, School of Veterinary Medicine, Azabu University, 1-17-71, Fuchinobe, Sagamihara, Kanagawa, 252-5201, Japan.
Parasitol Res. 2020 Sep;119(9):3093-3097. doi: 10.1007/s00436-020-06778-1. Epub 2020 Jun 26.
The efficacy of pyrantel pamoate, pyrvinium pamoate, ivermectin, and piperazine citrate against pinworm in cockroach was evaluated. Laboratory-reared German cockroaches naturally infected with Blatticola blattae were treated with the anthelmintics and necropsied at 3 to 35 days after treatment. Ivermectin at over 5 ppm and piperazine citrate at over 2000 ppm killed all the treated cockroaches. Pinworms were still detected in cockroaches given lower concentration of the aforementioned drugs. Administration of pyrantel pamoate (100-1000 ppm) and pyrvinium pamoate (2000 ppm) did not kill the cockroaches, and no pinworms were detected at 3 and 17 days after treatment. Thus, pyrantel pamoate and pyrvinium pamoate were found to be effective for deworming B. blattae in the German cockroaches, without causing mortality for the host. Our results showed that anthelmintics selection is essential for eradication of pinworms in cockroaches because of the toxicity for the host such as ivermectin or piperazine citrate. This is the first report of piperazine citrate toxicity in cockroaches.
评价了噻嘧啶、匹莫苯、伊维菌素和柠檬酸哌嗪对感染德国蟑螂的蛲虫的疗效。用驱虫剂处理自然感染 Blatticola blattae 的实验室饲养的德国蟑螂，并在处理后 3 至 35 天进行剖检。伊维菌素超过 5ppm 和柠檬酸哌嗪超过 2000ppm 可杀死所有处理过的蟑螂。在给予上述药物较低浓度的蟑螂中仍检测到蛲虫。给予噻嘧啶（100-1000ppm）和匹莫苯（2000ppm）不会杀死蟑螂，并且在处理后 3 天和 17 天未检测到蛲虫。因此，噻嘧啶和匹莫苯被发现对德国蟑螂的蛲虫有驱虫作用，而不会对宿主造成死亡率。我们的结果表明，由于伊维菌素或柠檬酸哌嗪等对宿主的毒性，驱虫剂的选择对于蟑螂体内的蛲虫根除至关重要。这是柠檬酸哌嗪对蟑螂毒性的首次报道。
