越南海绵 Gelliodes sp. 的化学成分及其细胞毒性。

Chemical Constituents of the Vietnamese Marine Sponge Gelliodes sp. and Their Cytotoxic Activities.

机构信息

Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan.

Pharmaceutical and Drug Industries Research Division, Pharmacognosy Department, National Research Centre, P.O. Box 12622, 33 El Bohouth St. (Former El Tahrir St.), Dokki, Giza, Egypt.

出版信息

Chem Biodivers. 2020 Sep;17(9):e2000303. doi: 10.1002/cbdv.202000303. Epub 2020 Aug 19.

DOI:10.1002/cbdv.202000303

PMID:32592287

Abstract

A new decenoic acid derivative, gelliodesinic acid, and a naturally new alkaloid, together with three known furanoterpenoids and two known indole alkaloids, were isolated from the MeOH extract of the marine sponge Gelliodes sp. collected in Vietnam. The chemical structures of the isolated compounds were determined by analyses of 1D- and 2D-NMR and MS data and by comparisons of the data with those reported in the literature. The cytotoxicity assay against HeLa, MCF-7, and A549 cancer cell lines revealed that the three known furanoterpenes exhibited cytotoxic activities with IC values ranging from 23.6 to 75.5 μM against the three cell lines, and that 1H-indole-3-carboxylic acid showed cytotoxicity with an IC value of 89.2 μM against A549 cancer cell lines.

摘要

从越南采集的海绵 Gelliodes sp 的 MeOH 提取物中分离得到一种新的癸酸衍生物凝胶酸和一种新的生物碱，以及三种已知的呋喃萜类化合物和两种已知的吲哚生物碱。通过对 1D 和 2D-NMR 以及 MS 数据的分析，并与文献报道的数据进行比较，确定了分离化合物的化学结构。对 HeLa、MCF-7 和 A549 癌细胞系的细胞毒性测定表明，三种已知的呋喃萜类化合物对三种细胞系的 IC 值范围为 23.6 至 75.5 μM，具有细胞毒性，而 1H-吲哚-3-羧酸对 A549 癌细胞系的 IC 值为 89.2 μM，具有细胞毒性。