纳阿米定H和I，来自印度尼西亚海洋海绵查戈斯亮海绵的具有细胞毒性的咪唑生物碱。
Naamidines H and I, cytotoxic imidazole alkaloids from the Indonesian marine sponge Leucetta chagosensis.
作者信息
Tsukamoto Sachiko, Kawabata Tetsuro, Kato Hikaru, Ohta Tomihisa, Rotinsulu Henki, Mangindaan Remy E P, van Soest Rob W M, Ukai Kazuyo, Kobayashi Hisayoshi, Namikoshi Michio
机构信息
Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, Japan.
出版信息
J Nat Prod. 2007 Oct;70(10):1658-60. doi: 10.1021/np070246i. Epub 2007 Sep 7.
PMID:17822294
Abstract
Two new imidazole alkaloids, naamidines H ( 1) and I ( 2), were isolated from the marine sponge Leucetta chagosensis, collected in North Sulawesi, Indonesia. The compounds ( 1 and 2) showed cytotoxicity against HeLa cells with IC50 values of 5.6 and 15 microg/mL, respectively.
摘要
从印度尼西亚北苏拉威西采集的海洋海绵查戈斯亮片海绵中分离出两种新的咪唑生物碱，namidines H（1）和I（2）。化合物（1和2）对HeLa细胞显示出细胞毒性，IC50值分别为5.6和15微克/毫升。
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