Tang Wei-Zhuo, Yang Zhong-Zhen, Sun Fan, Wang Shu-Ping, Yang Fan, Lin Hou-Wen
a Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy , Renji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai 200127 , China.
b School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
J Asian Nat Prod Res. 2017 Jul;19(7):691-696. doi: 10.1080/10286020.2016.1240171. Epub 2016 Oct 19.
Chemical investigation on CHCl extract of the marine sponge Leucandra sp. afforded two new compounds named leucanone A (1) and naamine J (2), together with eight known compounds (3-10). Their structures were elucidated on the basis of NMR spectroscopic analyses, and comparing with the literature. The cytotoxic activities of the compounds were evaluated against four cancer cell lines, and compound 2 showed mild cytotoxic activities against MCF-7, A549, HeLa, and PC9 cancer cell lines with IC values in the range of 20.1-45.3 μM.
对海洋海绵Leucandra sp.的氯仿提取物进行化学研究，得到了两种新化合物，分别命名为亮氨酸酮A（1）和纳胺J（2），以及八种已知化合物（3 - 10）。通过核磁共振光谱分析并与文献对比确定了它们的结构。评估了这些化合物对四种癌细胞系的细胞毒性活性，化合物2对MCF - 7、A549、HeLa和PC9癌细胞系表现出轻微的细胞毒性活性，IC值在20.1 - 45.3 μM范围内。
