Department of Pharmacy, Faculty of Science, Noakhali Science and Technology University, Noakhali, Bangladesh.
Asian Pac J Cancer Prev. 2020 Jun 1;21(6):1511-1519. doi: 10.31557/APJCP.2020.21.6.1511.
A transversion missense polymorphism of the TP53 tumor suppressor gene at the codon 72 codes proline instead of arginine causes an altered p53 protein expression and has been found to be associated with an elevated risk of various cancer; especially breast and lung cancer. As the previous case-control studies on the South Asian population have shown controversial results, we performed a meta-analysis to evaluate a precise estimation of the relationship between the TP53 Arg72Pro polymorphism with breast and lung cancer.
A total of 12 related studies on the South Asian population have been included through comprehensive database searching. Six studies were selected for breast cancer meta-analysis involving 950 cases and 882 controls; the other six studies were for lung cancer meta-analysis including 975 cases and 1397 controls. The results have been determined by using the Review Manager (RevMan) 5.3. Additionally, the stability of our analysis was assessed by heterogeneity, publication bias analysis and sensitivity testing.
A significantly increased risk of breast cancer was found in Pro allele (Pro vs. Arg), co-dominant model 2 (Pro/Pro vs. Arg/Arg), dominant model (Pro/Pro + Arg/Pro vs. Arg/Arg). In case of lung cancer, significantly increased risk was found in the allele, co-dominant 1, co-dominant 2, co-dominant 3, dominant, and recessive models. No association with other genetic models with breast and lung cancer risk was found in the South Asian population.
Our results indicate that TP53 Arg72Pro polymorphism is a risk factor for the development of breast cancer and lung cancer in the South Asian population.
TP53 肿瘤抑制基因的密码子 72 处的颠换错义多态性将脯氨酸取代为精氨酸，导致 p53 蛋白表达改变，并且已发现与各种癌症（尤其是乳腺癌和肺癌）的风险增加相关。由于之前对南亚人群的病例对照研究结果存在争议，我们进行了荟萃分析，以评估 TP53 Arg72Pro 多态性与乳腺癌和肺癌之间关系的更精确估计。
通过全面的数据库搜索，共纳入了 12 项关于南亚人群的相关研究。选择了 6 项研究进行乳腺癌荟萃分析，涉及 950 例病例和 882 例对照；另外 6 项研究用于肺癌荟萃分析，包括 975 例病例和 1397 例对照。结果通过 Review Manager（RevMan）5.3 确定。此外，还通过异质性、发表偏倚分析和敏感性测试评估了我们分析的稳定性。
在南亚人群中，Pro 等位基因（Pro 与 Arg）、共显性模型 2（Pro/Pro 与 Arg/Arg）和显性模型（Pro/Pro + Arg/Pro 与 Arg/Arg）中发现乳腺癌的风险显著增加。在肺癌中，在等位基因、共显性 1、共显性 2、共显性 3、显性和隐性模型中发现风险显著增加。在南亚人群中，未发现与其他遗传模型与乳腺癌和肺癌风险之间存在关联。
我们的结果表明，TP53 Arg72Pro 多态性是南亚人群乳腺癌和肺癌发展的危险因素。
