Assessing the influence of TP53 polymorphisms and haplotypes on bioelectrical impedance analysis parameters and nutritional status in aging Iranian population.

BACKGROUND

Sarcopenia is an age-related condition characterized by progressive loss of muscle mass, strength, and function, significantly impairing quality of life in older adults. This study investigated the association between three TP53 genetic variants (rs1625895, rs1042522, and rs17878362) and their haplotypes with Bioelectrical Impedance Analysis (BIA) parameters and nutritional status in elderly Iranian individuals.

METHODS AND RESULTS

The TP53 rs1625895 variant showed a significant association with nutritional status (P = 0.017). The TP53 exon 4 Arg72Pro polymorphism (rs1042522) influenced several BIA parameters, including calf circumference (P = 0.013), protein levels (P = 0.022), mineral levels (P = 0.049), body cell mass (BCM; P = 0.027), and arm muscle circumference (AMC; P = 0.010). The CC genotype exhibited significantly higher values than the TC genotype. Significant differences were observed among TP53 haplotypes for protein levels (P = 0.012), mineral levels (P = 0.020), fat-free mass (FFM; P = 0.033), BCM (P = 0.012), and bone mineral content (BMC; P = 0.043). The Arg/ins haplotype demonstrated the highest values compared to other haplotypes.

CONCLUSION

Our results highlight the potential role of TP53 polymorphisms and haplotypes in modulating BIA-derived parameters related to muscle health and sarcopenia. These findings underscore the complex interplay between genetic factors and physiological outcomes in aging populations. Further research is needed to elucidate the mechanistic pathways underlying these associations.