伊朗对 ASCO 预防急性化疗所致恶心和呕吐的依从性。
Adherence to ASCO for Prophylaxis of Acute Chemotherapy- Induced Nausea and Vomiting in Iran.
机构信息
Department of Clinical Pharmacy, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Oncology/Hematology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Asian Pac J Cancer Prev. 2020 Jun 1;21(6):1567-1572. doi: 10.31557/APJCP.2020.21.6.1567.
INTRODUCTION
Chemotherapy-induced nausea and vomiting (CINV) is one of the scariest chemotherapy-induced adverse effects. We evaluated the adherence to the 2017 American Society of Clinical Oncology (ASCO), the latest guideline recommendations, for the management of acute CINV at our institute.
METHODS
During a 6-months cross-sectional study on outpatient's cancer patients, we collected data from the prescription documents during temporary hospitalization and compared the results with ASCO guideline recommendations.
RESULTS
The most prescribed prophylactic regimens for the management of CINV were combination of aprepitant, granisetron, and dexamethasone and metoclopramide (51.8%). Regarding prescription compatibility in our center with ASCO guideline recommnedations, selection of different regimens for prophylaxis of acute CINV in our institute was compliant in 0 %, 22%, 4%, and 40% of high, moderate, low, and minimal emetogenic potential of chemotherapy regimen groupss, respectively.
CONCLUSION
Although our hospital is a referral and university-affiliated center, adherence to the ASCO guideline recommendations for prophylaxis of CINV was poor.
简介
化疗引起的恶心和呕吐（CINV）是最可怕的化疗相关不良反应之一。我们评估了我院在急性 CINV 管理方面对 2017 年美国临床肿瘤学会（ASCO）最新指南建议的遵循情况。
方法
在一项为期 6 个月的门诊癌症患者的横断面研究中，我们从临时住院期间的处方文件中收集数据，并将结果与 ASCO 指南建议进行比较。
结果
预防 CINV 的最常开处方方案是阿瑞匹坦、格拉司琼和地塞米松与甲氧氯普胺的联合方案（51.8%）。关于我院与 ASCO 指南建议的处方相容性，我院在预防高、中、低和轻度致吐性化疗方案组的急性 CINV 中，分别有 0%、22%、4%和 40%的方案选择符合指南建议。
结论
尽管我们的医院是一家转诊和附属大学的中心，但在预防 CINV 方面，对 ASCO 指南建议的遵循情况较差。
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