Karimi Sahar, Vaez Mehrnaz, Aria Amir, Sharifi Mehran, Moghaddas Azadeh
Department of Clinical Pharmacy, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Internal Medicine, School of Medicine, Cancer Prevention Research Center, Seyyed Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Caspian J Intern Med. 2025 Mar 21;16(2):355-361. doi: 10.22088/cjim.16.2.355. eCollection 2025 Spring.
Medication errors are a significant cause of adverse events in cancer patients. The study aimed to investigate unintentional medication errors during chemotherapy regimen prescription.
During the six months' follow-ups, 201 adult patients admitted to outpatients' chemotherapy ward of Omid Hospital, Isfahan, Iran were examined. An information checklist by the aim of data gathering including patients' demographic information, laboratory data, medications history, chemotherapy drug doses and protocol of administration, pre-medications drugs, and supportive treatment was prepared. The data was compared by standard guidelines and data were presented in percent and frequency.
Among the enrolled patients, 327 errors were identified. Sixty-five percent of patients were females and the mean age of patients was 49.2±2.8 years old. Gastrointestinal and breast cancers were among the most frequently reported cancers. The highest frequency of errors (67.27%) was attributed to the prescription of pre-medication drug administration primarily in the management of chemotherapy-induced nausea and vomiting. Medication errors in selection and volume of infused serums (20.18%) and in adjusting the dosage of chemotherapy regimens (10.39%) were the most observed errors.
This study highlighted the important areas to improve cancer management at the medical center. By addressing these challenges and implementing necessary changes, the center can enhance the quality of care provided to cancer patients, ensure adherence to international standards, and improve patient outcomes.
用药错误是癌症患者不良事件的一个重要原因。本研究旨在调查化疗方案处方期间的无意用药错误。
在为期六个月的随访期间，对伊朗伊斯法罕奥米德医院门诊化疗病房收治的201名成年患者进行了检查。准备了一份用于收集数据的信息清单，包括患者的人口统计学信息、实验室数据、用药史、化疗药物剂量和给药方案、预处理药物以及支持性治疗。将数据与标准指南进行比较，并以百分比和频率呈现数据。
在纳入的患者中，共识别出327处错误。65%的患者为女性，患者的平均年龄为49.2±2.8岁。胃肠道癌和乳腺癌是报告频率最高的癌症类型。错误发生率最高的是预处理药物的处方（67.27%），主要用于化疗引起的恶心和呕吐的管理。输注血清的选择和用量方面的用药错误（20.18%）以及化疗方案剂量调整方面的用药错误（10.39%）是最常见的错误。
本研究突出了医疗中心改善癌症管理的重要领域。通过应对这些挑战并实施必要的变革，该中心可以提高为癌症患者提供的护理质量，确保符合国际标准，并改善患者预后。
