儿童感染 COVID-19 时的免疫反应特点是 T 细胞活化水平低于感染的成年人。
Immune response in children with COVID-19 is characterized by lower levels of T-cell activation than infected adults.
机构信息
From Flow Cytometry Laboratory, Clinical Chemistry Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy.
Department of Clinical and Experimental Sciences, University of Brescia and A. Nocivelli Institute of Molecular Medicine, Brescia, Italy.
出版信息
Eur J Immunol. 2020 Sep;50(9):1412-1414. doi: 10.1002/eji.202048724. Epub 2020 Jul 29.
Study of immunological features of immune response in 14 children (aged from 12 days up to 15 years) and of 10 adults who developed COVID-19 show increased number of activated CD4 and CD8 cells expressing DR and higher plasmatic levels of IL-12 and IL-1β in adults with COVID-19, but not in children. In addition, plasmatic levels of CCL5/RANTES are higher in children and adults with COVID-19, while CXCL9/MIG was only increased in adults. Higher number of activated T cells and expression of IL-12 and CXCL9 suggest prominent Th1 polarization of immune response against SARS-CoV2 in infected adults as compared with children.
研究了 14 名儿童（年龄从 12 天至 15 岁）和 10 名成年人的免疫反应的免疫学特征，这些成年人患有 COVID-19。结果表明，与儿童相比，患有 COVID-19 的成年人中表达 DR 的活化 CD4 和 CD8 细胞数量增加，IL-12 和 IL-1β 的血浆水平更高。此外，患有 COVID-19 的儿童和成年人的血浆 CCL5/RANTES 水平更高，而 CXCL9/MIG 仅在成年人中增加。与儿童相比，感染 SARS-CoV2 的成年人中活化 T 细胞数量增加，IL-12 和 CXCL9 的表达增加，表明针对 SARS-CoV2 的免疫反应存在明显的 Th1 极化。
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