一种与转化相关的130kD细胞表面糖蛋白在正常人细胞中受生长调控。
A transformation-associated 130-kD cell surface glycoprotein is growth controlled in normal human cells.
作者信息
Klein C E, Ozer H L, Traganos F, Atzpodien J, Oettgen H F, Old L J
机构信息
Memorial Sloan-Kettering Cancer Center, New York 10021.
出版信息
J Exp Med. 1988 May 1;167(5):1684-96. doi: 10.1084/jem.167.5.1684.
Abstract
Two characteristics of cell surface molecules involved in the regulation of cell proliferation are altered expression in relation to growth phase in normal cells and overexpression in transformed cells. Here, we describe a similar pattern of expression for a 130-kD cell surface glycoprotein (gp 130) in human cells. Synthesis and cell surface expression of gp130 were greatly increased in both virally and chemically transformed fibroblasts, fibrosarcomas, a squamous cell carcinoma of the skin, and T cell leukemia lines. Furthermore, gp130 expression was induced in serum-starved fetal fibroblasts by serum stimulation, and in fresh T cells by various activating agents. Expression in response to serum stimulation was associated primarily with the transition from a quiescent state (G0) into the cell cycle (G1).
摘要
参与细胞增殖调控的细胞表面分子有两个特点，即正常细胞中其表达会随生长阶段发生改变，而在转化细胞中则会过度表达。在此，我们描述了人类细胞中一种130-kD细胞表面糖蛋白（gp130）的类似表达模式。gp130的合成及细胞表面表达在病毒转化和化学转化的成纤维细胞、纤维肉瘤、皮肤鳞状细胞癌以及T细胞白血病细胞系中均显著增加。此外，血清刺激可诱导血清饥饿的胎儿成纤维细胞表达gp130，各种激活剂可诱导新鲜T细胞表达gp130。血清刺激后的表达主要与从静止状态（G0）过渡到细胞周期（G1）相关。
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