Hospital pharmacy, Hospital San Cecilio, Granada, Spain.
Br J Clin Pharmacol. 2021 Mar;87(3):1525-1528. doi: 10.1111/bcp.14445. Epub 2020 Aug 3.
We observed a severe case of cerebral toxoplasmosis in a 22-year-old woman diagnosed with dermatomyositis in 2016 in Venezuela, and treated with rituximab and azathioprine. The patient met clinical and microbiological criteria. Treatment with pyrimethamine and sulfadiazine was initiated, and the patient was discharged. She was rehospitalized with signs and symptoms of a manic episode. During hospitalization, the patient developed acute kidney injury related to sulfadiazine crystalluria. Finally, acute kidney injury was resolved and the patient was successfully discharged.
我们观察到一名 22 岁的委内瑞拉女性患有皮肌炎，于 2016 年被确诊，并接受利妥昔单抗和硫唑嘌呤治疗。该患者符合临床和微生物学标准。开始使用乙胺嘧啶和磺胺嘧啶进行治疗，随后患者出院。她因躁狂发作的迹象和症状再次入院。住院期间，患者因磺胺嘧啶结晶尿引起急性肾损伤。最终，急性肾损伤得到解决，患者成功出院。
