List Edward O, Duran-Ortiz Silvana, Kopchick John J
Edison Biotechnology Institute, Ohio University, Athens, OH, 45701, USA; Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, 45701, USA.
Edison Biotechnology Institute, Ohio University, Athens, OH, 45701, USA; Molecular and Cellular Biology Program, Department of Biomedical Sciences, Ohio University, Athens, OH, 45701, USA.
Mol Cell Endocrinol. 2020 Sep 15;515:110919. doi: 10.1016/j.mce.2020.110919. Epub 2020 Jun 24.
Growth hormone (GH) is pituitary derived hormone which acts on most tissues of the body either directly or indirectly and affects many metabolic processes throughout life. Genetically engineered mouse lines have become vital tools for uncovering the various in vivo activities of a GH. A particularly useful mouse line has been the GH receptor (GHR) gene disrupted or knockout (KO) mouse which has been used world-wide in many studies. Recent advances in biotechnology have allowed the development of tissue-specific knockout mouse lines which allows for more direct enquiries on the activities of a given protein in specific tissues or cell types. Accordingly, twenty-two novel tissue-specific GHRKO mouse lines have been developed in the last eleven years. In this paper we provide a detailed list and review the phenotypic changes that occur in each of these tissue-specific GHRKO mouse lines.
生长激素（GH）是一种由垂体分泌的激素，它直接或间接地作用于身体的大多数组织，并影响一生中的许多代谢过程。基因工程小鼠品系已成为揭示生长激素各种体内活性的重要工具。一种特别有用的小鼠品系是生长激素受体（GHR）基因缺失或敲除（KO）小鼠，它已在全球范围内被用于许多研究。生物技术的最新进展使得组织特异性敲除小鼠品系得以开发，这使得能够更直接地研究特定组织或细胞类型中特定蛋白质的活性。因此，在过去的十一年里，已经开发出了二十二种新型的组织特异性GHRKO小鼠品系。在本文中，我们提供了一份详细的清单，并回顾了这些组织特异性GHRKO小鼠品系中每一种所发生的表型变化。
