Sommer Maja Schick, Vibe-Petersen Jette, Stærkind Maja Bohlbro, Langer Seppo W, Larsen Klaus Richter, Trier Karen, Christensen Merete, Clementsen Paul F, Missel Malene, Christensen Karl Bang, Lillelund Christian, Langberg Henning, Pedersen Jesper H, Quist Morten
Copenhagen Centre for Cancer and Health, Denmark.
Copenhagen Centre for Cancer and Health, Denmark.
Lung Cancer. 2020 Aug;146:285-289. doi: 10.1016/j.lungcan.2020.06.023. Epub 2020 Jun 20.
Patients with lung cancer report a lower degree of Health Related Quality of Life (HRQoL) compared with other cancer patients. HRQoL reflects how patients experience the impact of their disease and its treatment on their quality of daily living. A widely used questionnaire in lung cancer patients is the Functional Assessment of Cancer Therapy - Lung (FACT-L) questionnaire. Here we report the secondary outcomes on FACT-L data from the Postoperative Rehabilitation in Operation for Lung CAncer (PROLUCA) study, which describes the effect of early (14 days) versus late initiated (14 weeks) postoperative rehabilitation.
The PROLUCA study was designed as a two-armed randomized controlled trial with an early rehabilitation group (14 days after surgery (ERG)) or a control arm with a late rehabilitation group (14 weeks after surgery (LRG)). The results for seven domain scores obtained using the FACT-L at the following time-points: baseline, 14 weeks, 26 weeks and 52 weeks after surgery are presented here.
119 patients were randomized to the ERG and 116 to the LRG. In the ERG, HRQoL measured by both FACT-L and FACT-G (general core instrument) showed a continuous improvement up to 26 weeks after which HRQoL decreased after further 26 weeks without structured intervention. In the LRG a non-significant deterioration was detected over the first 14 weeks after surgery. After participation in the 12 weeks rehabilitation program, an increase in HRQoL was seen, without reaching the same level as the early group.
Analyses of the seven domain scores obtained using FACT-L and FACT-G reflect the importance of starting exercise early after surgery since the ERG avoid a temporary decrease in HRQoL. It is therefore recommended to start up a structured rehabilitation program 14 days after surgery, containing high intensity interval training and strength exercise twice a week for 12 weeks.
与其他癌症患者相比，肺癌患者报告的健康相关生活质量（HRQoL）较低。HRQoL反映了患者如何体验疾病及其治疗对其日常生活质量的影响。肺癌患者广泛使用的问卷是癌症治疗功能评估-肺癌（FACT-L）问卷。在此，我们报告了肺癌手术术后康复（PROLUCA）研究中FACT-L数据的次要结果，该研究描述了早期（14天）与晚期开始（14周）术后康复的效果。
PROLUCA研究设计为双臂随机对照试验，分为早期康复组（术后14天（ERG））或晚期康复对照组（术后14周（LRG））。这里展示了在以下时间点使用FACT-L获得的七个领域得分的结果：基线、术后14周、26周和52周。
119名患者被随机分配到ERG组，116名患者被随机分配到LRG组。在ERG组中，通过FACT-L和FACT-G（通用核心工具）测量的HRQoL在术后26周前持续改善，之后在没有结构化干预的情况下，HRQoL在接下来的26周下降。在LRG组中，术后前14周检测到非显著性恶化。参与12周康复计划后，HRQoL有所提高，但未达到早期组的水平。
对使用FACT-L和FACT-G获得的七个领域得分的分析反映了术后早期开始运动的重要性，因为ERG组避免了HRQoL的暂时下降。因此，建议在术后14天开始一个结构化的康复计划，包括高强度间歇训练和每周两次的力量训练，持续12周。
