Nutrition Institute, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Social Medicine Institute, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Nutrition. 2020 Oct;78:110865. doi: 10.1016/j.nut.2020.110865. Epub 2020 May 16.
The aim of this study was to investigate the association between phase angle (PhA) and first cardiovascular (CV) event risk.
This was a cross-sectional study. PhA was determined using a single-frequency bioelectrical impedance analyzer. Scores from the American College of Cardiology/American Heart Association (ACC/AHA; N = 455; 49% men) and the Framingham General Cardiovascular (FRS-CVD; N = 489; 49% men) were used to estimate the risk for a first CV event in adults. Logistic and multinomial regressions were used to evaluate the relationship between ACC/AHA and FRS-CVD risk scores (outcomes) and PhA. Additionally, the consumption of in natura or minimally processed foods was included in the models as an adjustment variable.
Men and women, classified according to ACC/AHA (P < 0.001; P = 0.035) and FRS-CVD scores (P = 0.002; P = 0.012) as low risk for first event CV, presented higher PhA values than participants with elevated risk. However, only in men categorized as CV high risk, the third PhA tertile (>7.3°) was associated with a CV lower risk (ACC/AHA, odds ratio, 0.28; 95% confidence interval [CI], 0.14-0.56; FRS-CVD, relative risk ratio, 0.11; 95% CI, 0.03-0.37). The adjustment of all models for consumption of in natura or minimally processed foods did not change the results.
Higher PhA values were associated with lower risk for a first CV event in men classified in higher-risk categories. In natura or minimally processed food consumption did not influence the relationship between PhA and CV risk. These results may encourage future research about possible applications of PhA as an additional index in primary prevention of CV events.
本研究旨在探讨相位角（PhA）与首次心血管（CV）事件风险之间的关联。
这是一项横断面研究。使用单相生物电阻抗分析仪测定 PhA。美国心脏病学会/美国心脏协会（ACC/AHA；N=455；49%为男性）和弗雷明汉心血管总风险评分（FRS-CVD；N=489；49%为男性）的评分用于估计成年人首次 CV 事件的风险。使用逻辑回归和多项回归评估 ACC/AHA 和 FRS-CVD 风险评分（结局）与 PhA 之间的关系。此外，在模型中还纳入了食用天然或最低限度加工食品作为调整变量。
根据 ACC/AHA（P<0.001；P=0.035）和 FRS-CVD 评分（P=0.002；P=0.012）分类为首次 CV 事件低危的男性和女性，其 PhA 值高于风险升高的参与者。然而，仅在男性中，CV 高危者的第三 PhA 三分位（>7.3°）与 CV 风险降低相关（ACC/AHA，优势比，0.28；95%置信区间[CI]，0.14-0.56；FRS-CVD，相对风险比，0.11；95%CI，0.03-0.37）。对所有模型进行食用天然或最低限度加工食品的调整并未改变结果。
在分类为高危的男性中，较高的 PhA 值与首次 CV 事件风险降低相关。食用天然或最低限度加工食品并未影响 PhA 与 CV 风险之间的关系。这些结果可能鼓励未来研究 PhA 作为 CV 事件一级预防的附加指标的可能应用。
