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糖化血红蛋白 (HbA1c) 与青年相扑选手的生物电阻抗相位角独立相关:一项初步研究。

Glycated hemoglobin (HbA1c) is independently associated with the bioelectrical impedance phase angle in junior sumo wrestlers: A pilot study.

机构信息

Doctoral Program in Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.

Department of Pediatrics, Japanese Red Cross Nasu Hospital, Tochigi, Japan.

出版信息

Physiol Rep. 2024 May;12(9):e16045. doi: 10.14814/phy2.16045.

DOI:10.14814/phy2.16045
PMID:38740565
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11090887/
Abstract

The study explores the relationship between phase angle (PhA), an indicator of cellular health, and metabolic health parameters among junior sumo wrestlers in Japan. Given the demanding lifestyle and high-energy diets of sumo wrestlers that predispose them to metabolic syndrome post-retirement, this study focuses on a younger cohort. The primary aim is to evaluate if PhA could serve as an early indicator of metabolic health issues within this unique demographic. A total of 14 sumo wrestlers aged 9-17 years were assessed to determine the relationship between PhA and various metabolic markers, including glycated hemoglobin (HbA1c), using a TANITA MC-780A-N body composition analyzer and standard blood tests. Bivariate regression analysis and Pearson's correlation revealed a negative relationship between PhA and HbA1c even after adjusting for age and weight (ß = -0.496, r = 0.776, r = -0.756, p = 0.004). The results indicate a significant negative relationship between PhA and HbA1c levels, suggesting that lower PhA values, which indicate poorer cellular integrity, are associated with higher HbA1c levels, signifying impaired glycemic control. These findings underscore the potential of PhA as a valuable biomarker for monitoring metabolic health in young sumo wrestlers, with implications for early intervention and management strategies.

摘要

本研究旨在探讨相角(PhA)与代谢健康参数之间的关系,相角是细胞健康的一个指标,研究对象为日本青少年相扑选手。鉴于相扑选手的生活方式要求苛刻,且他们的高能量饮食会导致他们在退役后面临代谢综合征的风险,因此本研究侧重于这一年轻群体。主要目的是评估 PhA 是否可以作为这一独特人群代谢健康问题的早期指标。本研究共评估了 14 名年龄在 9 至 17 岁的相扑选手,使用 TANITA MC-780A-N 身体成分分析仪和标准血液测试来确定 PhA 与各种代谢标志物(包括糖化血红蛋白(HbA1c))之间的关系。双变量回归分析和 Pearson 相关性分析显示,即使在校正年龄和体重后,PhA 与 HbA1c 之间仍存在负相关关系(ß= -0.496,r= 0.776,r= -0.756,p= 0.004)。研究结果表明 PhA 与 HbA1c 水平之间存在显著的负相关关系,这表明 PhA 值较低(表明细胞完整性较差)与 HbA1c 水平较高(表示血糖控制受损)相关。这些发现突显了 PhA 作为监测年轻相扑选手代谢健康的有价值生物标志物的潜力,对早期干预和管理策略具有重要意义。

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Phase Angle as a Potential Screening Tool in Adults with Metabolic Diseases in Clinical Practice: A Systematic Review.相位角作为临床实践中代谢性疾病成人的潜在筛查工具:系统评价。
Int J Environ Res Public Health. 2023 Jan 16;20(2):1608. doi: 10.3390/ijerph20021608.
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Phase angle (PhA) in overweight and obesity: evidence of applicability from diagnosis to weight changes in obesity treatment.相位角(PhA)在超重和肥胖中的应用:肥胖治疗中从诊断到体重变化的证据。
Rev Endocr Metab Disord. 2023 Jun;24(3):451-464. doi: 10.1007/s11154-022-09774-1. Epub 2022 Dec 9.
3
Phase angle and cellular health: inflammation and oxidative damage.
相位角与细胞健康:炎症与氧化损伤。
Rev Endocr Metab Disord. 2023 Jun;24(3):543-562. doi: 10.1007/s11154-022-09775-0. Epub 2022 Dec 7.
4
Comparative evaluation of obesity-related parameters in junior sumo wrestlers and children with obesity.相扑少年选手与肥胖儿童肥胖相关参数的比较评估
Phys Act Nutr. 2021 Sep;25(3):36-43. doi: 10.20463/pan.2021.0019. Epub 2021 Sep 30.
5
The relationship between high-density lipoprotein cholesterol (HDL-C) and glycosylated hemoglobin in diabetic patients aged 20 or above: a cross-sectional study.20 岁及以上糖尿病患者高密度脂蛋白胆固醇(HDL-C)与糖化血红蛋白的关系:一项横断面研究。
BMC Endocr Disord. 2021 Oct 11;21(1):198. doi: 10.1186/s12902-021-00863-x.
6
Raw bioelectrical impedance analysis variables (phase angle and impedance ratio) are significant predictors of hand grip strength in adolescents and young adults.原始生物电阻抗分析变量(相位角和阻抗比)是青少年和年轻成人握力的重要预测指标。
Nutrition. 2021 Nov-Dec;91-92:111445. doi: 10.1016/j.nut.2021.111445. Epub 2021 Aug 10.
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Phase angle association with metabolic profile in adults: A population-based study.相位角与成年人代谢特征的关联:一项基于人群的研究。
Nutrition. 2021 Oct;90:111233. doi: 10.1016/j.nut.2021.111233. Epub 2021 Mar 7.
8
The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System.2 型糖尿病对器官代谢和免疫系统的影响。
Front Immunol. 2020 Jul 22;11:1582. doi: 10.3389/fimmu.2020.01582. eCollection 2020.
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