Medical School, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Porto Alegre, Brazil.
Medical School, Universidade do Vale do Rio dos Sinos, UNISINOS, São Leopoldo, Brazil.
BMC Cardiovasc Disord. 2024 Oct 29;24(1):606. doi: 10.1186/s12872-024-04211-4.
Cardiovascular diseases are characterized by chronic inflammation, leading to increased inflammatory markers that can cause cell damage and death. Phase angle has emerged as a marker of cellular health. It is considered a prognostic factor in various acute and chronic conditions. However, few studies have examined its association with cardiovascular disease risk measures. This study aims to investigate the relationship between phase angle, the general Framingham risk score, and the HEARTS cardiovascular risk score.
This cross-sectional study included a convenience sample of adult patients of 2 primary health care services. Phase angle was measured using multifrequency bioimpedance analysis at 50 kHz. The risk of cardiovascular events was calculated using the Framingham and HEARTS risk scores. Statistical analysis included generalized linear regression models, unadjusted and adjusted according to sex and age, to determine the association between scores, risk factors, and phase angle.
The study included 164 individuals with a mean age 52.2 (SD 17.9). According to the HEARTS score, low-risk patients had higher phase angle values than those with high or very high risk [ß = -0.57 (95% CI -0.95; -0.19), P = 0.003]. Framingham scores showed a trend toward significance for higher mean phase angle values in low-risk than high-risk patients [ß = -0.43 (95% CI -0.88 to 0.02), P = 0.06].
Phase angle values were lower in high and very high-risk patients than in low-risk patients, which shows that phase angle is a promising risk predictor for patients with cardiovascular diseases.
心血管疾病的特征是慢性炎症，导致炎症标志物增加，从而导致细胞损伤和死亡。相位角已成为细胞健康的标志物。它被认为是各种急性和慢性疾病的预后因素。然而，很少有研究探讨其与心血管疾病风险指标的关系。本研究旨在探讨相位角与一般弗雷明汉风险评分和 HEARTS 心血管风险评分之间的关系。
这是一项横断面研究，纳入了 2 家初级保健服务机构的成年患者的便利样本。使用 50 kHz 的多频生物阻抗分析测量相位角。使用弗雷明汉和 HEARTS 风险评分计算心血管事件的风险。统计分析包括广义线性回归模型，根据性别和年龄进行未经调整和调整，以确定评分、危险因素和相位角之间的关联。
该研究纳入了 164 名平均年龄为 52.2（SD 17.9）的个体。根据 HEARTS 评分，低危患者的相位角值高于高危或极高危患者[β=-0.57（95%CI-0.95；-0.19），P=0.003]。弗雷明汉评分显示，低危患者的平均相位角值高于高危患者，有显著趋势[β=-0.43（95%CI-0.88 至 0.02），P=0.06]。
高危和极高危患者的相位角值低于低危患者，这表明相位角是预测心血管疾病患者风险的有前途的指标。
