Medical School of Nanchang University, 603 Bayi Road, Nanchang, Jiangxi 330006, China.
Biomed Pharmacother. 2020 Sep;129:110416. doi: 10.1016/j.biopha.2020.110416. Epub 2020 Jun 25.
Aberrant activation of Notch signaling plays an oncogenic role in cancer development. Jagged1 (JAG1) is an important Notch ligand that triggers Notch signaling through cell-cell interactions. JAG1 overexpression has been reported in many different types of cancer and correlates with a poor clinical prognosis. JAG1/Notch signaling controls oncogenic processes in different cell types and cellular contexts. Furthermore, JAG1/Notch signaling cascades activate a number of oncogenic factors that regulate cellular functions such as proliferation, metastasis, drug-resistance, and angiogenesis. To suppress the severe toxicity of pan-Notch inhibitors, JAG1 is attracting increasing attention as a source of therapeutic targets for cancers. In this review, the oncogenic role of JAG1/Notch signaling in cancer is discussed, as well as implications of strategies to inhibit JAG1/Notch signaling activity.
Notch 信号通路的异常激活在癌症的发生发展中起着致癌作用。Jagged1（JAG1）是一种重要的 Notch 配体，通过细胞间相互作用触发 Notch 信号通路。JAG1 的过表达已在许多不同类型的癌症中被报道，并与不良的临床预后相关。JAG1/Notch 信号通路在不同的细胞类型和细胞环境中控制致癌过程。此外，JAG1/Notch 信号级联激活了许多调节细胞功能的致癌因子，如增殖、转移、耐药性和血管生成。为了抑制泛 Notch 抑制剂的严重毒性，JAG1 作为癌症治疗靶点的来源越来越受到关注。在这篇综述中，讨论了 JAG1/Notch 信号通路在癌症中的致癌作用，以及抑制 JAG1/Notch 信号通路活性的策略的意义。
