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Engineering mesenchymal stromal/stem cell-derived extracellular vesicles with improved targeting and therapeutic efficiency for the treatment of central nervous system disorders.

作者信息

Iavorovschi Alexandra M, Wang Aijun

机构信息

Surgical Bioengineering Laboratory, Department of Surgery, School of Medicine, University of California-Davis; Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children-Northern California, Sacramento, CA, USA.

Surgical Bioengineering Laboratory, Department of Surgery, School of Medicine, University of California-Davis; Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children-Northern California, Sacramento; Department of Biomedical Engineering, University of California, Davis School of Engineering, Davis, CA, USA.

出版信息

Neural Regen Res. 2020 Dec;15(12):2235-2236. doi: 10.4103/1673-5374.284982.

DOI:10.4103/1673-5374.284982
PMID:32594034
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7749490/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/902c/7749490/895432e1212b/NRR-15-2235-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/902c/7749490/895432e1212b/NRR-15-2235-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/902c/7749490/895432e1212b/NRR-15-2235-g001.jpg

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Placental Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Myelin Regeneration in an Animal Model of Multiple Sclerosis.胎盘间充质干细胞衍生的细胞外囊泡促进多发性硬化症动物模型中的髓鞘再生。
Cells. 2019 Nov 23;8(12):1497. doi: 10.3390/cells8121497.
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Intranasal Delivery of Mesenchymal Stem Cell Derived Exosomes Loaded with Phosphatase and Tensin Homolog siRNA Repairs Complete Spinal Cord Injury.经磷酸酶和张力蛋白同源物 siRNA 负载的间充质干细胞衍生外泌体经鼻腔递送至修复完全性脊髓损伤。
ACS Nano. 2019 Sep 24;13(9):10015-10028. doi: 10.1021/acsnano.9b01892. Epub 2019 Aug 29.
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Neuroprotective effect of placenta-derived mesenchymal stromal cells: role of exosomes.
Int J Nanomedicine. 2024 Mar 6;19:2241-2264. doi: 10.2147/IJN.S446224. eCollection 2024.
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Hypoxic preconditioned MSCs-derived small extracellular vesicles for photoreceptor protection in retinal degeneration.缺氧预处理间充质干细胞来源的小细胞外囊泡在视网膜变性中的光感受器保护作用。
J Nanobiotechnology. 2023 Nov 25;21(1):449. doi: 10.1186/s12951-023-02225-2.
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Enhancing the Cellular Production of Extracellular Vesicles for Developing Therapeutic Applications.增强细胞外囊泡的细胞生产，以开发治疗应用。
Pharm Res. 2023 Apr;40(4):833-853. doi: 10.1007/s11095-022-03420-w. Epub 2022 Nov 1.
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Life (Basel). 2022 Sep 11;12(9):1417. doi: 10.3390/life12091417.
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J Extracell Vesicles. 2018 Sep 26;7(1):1522236. doi: 10.1080/20013078.2018.1522236. eCollection 2018.
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Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy.表面功能化的外泌体作为靶向递药载体用于脑缺血治疗。
Biomaterials. 2018 Jan;150:137-149. doi: 10.1016/j.biomaterials.2017.10.012. Epub 2017 Oct 4.
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Current knowledge on exosome biogenesis and release.外泌体生物发生和释放的最新知识。
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