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COVID-19 and outbreak of chilblains: are they related?新冠病毒与冻疮爆发:它们有关联吗?
J Eur Acad Dermatol Venereol. 2020 Dec;34(12):e757-e758. doi: 10.1111/jdv.16779. Epub 2020 Jul 21.
2
COVID toes: Phenomenon or epiphenomenon?新冠脚趾:是一种现象还是附带现象?
J Am Acad Dermatol. 2020 Nov;83(5):e347-e348. doi: 10.1016/j.jaad.2020.07.037. Epub 2020 Jul 17.
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Dermatology and COVID-19: Much knowledge to date but still a lot to discover.皮肤病学与新型冠状病毒肺炎:迄今已有诸多认识,但仍有许多有待探索。
Ann Dermatol Venereol. 2021 Jun;148(2):69-70. doi: 10.1016/j.annder.2021.03.001. Epub 2021 Mar 12.
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Further evidence that chilblains are a cutaneous manifestation of COVID-19 infection.冻疮是新冠病毒感染的一种皮肤表现的进一步证据。
Br J Dermatol. 2020 Sep;183(3):596-598. doi: 10.1111/bjd.19243. Epub 2020 Jun 25.
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Dermoscopy features of COVID-19-related chilblains in children and adolescents.儿童和青少年中与新型冠状病毒肺炎相关冻疮的皮肤镜特征
J Eur Acad Dermatol Venereol. 2020 Dec;34(12):e762-e764. doi: 10.1111/jdv.16800. Epub 2020 Jul 22.
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Concurrent chilblains and retinal vasculitis in a child with COVID-19.一名新冠病毒感染儿童并发冻疮和视网膜血管炎。
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Recent outbreak of chilblain-like lesions is not directly related to SARS-CoV-2 infection.近期冻疮样病变的爆发与新型冠状病毒感染没有直接关系。
J Eur Acad Dermatol Venereol. 2020 Nov;34(11):e689-e692. doi: 10.1111/jdv.16776. Epub 2020 Jul 28.
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Chilblains outbreak during COVID-19 pandemic: A Type-I interferonopathy?2019冠状病毒病大流行期间冻疮的爆发:一种Ⅰ型干扰素病?
Pediatr Allergy Immunol. 2022 Oct;33(10):e13860. doi: 10.1111/pai.13860.
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High prevalence of cryofibrinogenemia in patients with chilblains during the COVID-19 outbreak.新冠疫情期间冻疮患者中纤维蛋白原血症的高发率。
Int J Dermatol. 2020 Dec;59(12):1475-1484. doi: 10.1111/ijd.15234. Epub 2020 Oct 17.

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Enhanced TLR7-dependent production of type I interferon by pDCs underlies pandemic chilblains.浆细胞样树突状细胞(pDCs)中由Toll样受体7(TLR7)依赖性增强的I型干扰素产生是大流行冻疮的基础。
J Exp Med. 2025 Jul 7;222(7). doi: 10.1084/jem.20231467. Epub 2025 Apr 14.
2
Understanding COVID-19 in children: immune determinants and post-infection conditions.了解儿童 COVID-19:免疫决定因素和感染后状况。
Pediatr Res. 2023 Aug;94(2):434-442. doi: 10.1038/s41390-023-02549-7. Epub 2023 Mar 6.
3
SARS-CoV-2 Vaccination and Chilblain-like Lesions: What Do We Know so Far?新型冠状病毒2型疫苗接种与冻疮样病变:我们目前了解到了什么?
Dermatol Pract Concept. 2022 Oct 1;12(4):e2022170. doi: 10.5826/dpc.1204a170. eCollection 2022 Nov.
4
An Observational Study of Mucocutaneous Manifestations among SARS-CoV-2 Patients from Three COVID-19 Dedicated Tertiary Care Centers.一项对来自三个新冠肺炎定点三级护理中心的新冠病毒2型患者皮肤黏膜表现的观察性研究。
Indian Dermatol Online J. 2021 Sep 10;12(5):687-695. doi: 10.4103/idoj.IDOJ_127_21. eCollection 2021 Sep-Oct.
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Are the chilblain-like lesions observed during the COVID-19 pandemic due to severe acute respiratory syndrome coronavirus 2? Systematic review and meta-analysis.在 COVID-19 大流行期间观察到的冻疮样病变是否是由严重急性呼吸综合征冠状病毒 2 引起的?系统评价和荟萃分析。
J Eur Acad Dermatol Venereol. 2022 Jan;36(1):24-38. doi: 10.1111/jdv.17672. Epub 2021 Oct 5.
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Chilblain-like lesions after BNT162b2 mRNA COVID-19 vaccine: a case report suggesting that 'COVID toes' are due to the immune reaction to SARS-CoV-2.BNT162b2 mRNA新冠疫苗接种后出现冻疮样病变:一例病例报告提示“新冠脚趾”是由对严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的免疫反应所致
J Eur Acad Dermatol Venereol. 2021 Oct;35(10):e630-e632. doi: 10.1111/jdv.17451. Epub 2021 Jun 30.
7
Pediatric COVID toes and fingers.儿科新冠脚趾和手指。
Clin Dermatol. 2021 Jan-Feb;39(1):84-91. doi: 10.1016/j.clindermatol.2020.12.016. Epub 2021 Jan 14.
8
Chilblain-Like Lesions during COVID-19 Pandemic: The State of the Art.2019冠状病毒病大流行期间的冻疮样病变:最新进展
Life (Basel). 2021 Jan 2;11(1):23. doi: 10.3390/life11010023.
9
COVID toes: where do we stand with the current evidence?新冠脚趾:当前证据下我们处于什么位置?
Int J Infect Dis. 2021 Jan;102:53-55. doi: 10.1016/j.ijid.2020.10.021. Epub 2020 Oct 16.

本文引用的文献

1
Chilblain acral lesions in the COVID-19 era. Are they marker of infection in asymptomatic patients?新冠疫情时代的冻疮样肢端病变。它们是无症状患者感染的标志物吗?
J Eur Acad Dermatol Venereol. 2020 Sep;34(9):e440-e441. doi: 10.1111/jdv.16636. Epub 2020 Jun 8.
2
Type I IFN immunoprofiling in COVID-19 patients.新冠病毒感染患者的I型干扰素免疫谱分析
J Allergy Clin Immunol. 2020 Jul;146(1):206-208.e2. doi: 10.1016/j.jaci.2020.04.029. Epub 2020 Apr 29.
3
Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases.COVID-19 皮肤表现分类:西班牙 375 例快速前瞻性全国共识研究。
Br J Dermatol. 2020 Jul;183(1):71-77. doi: 10.1111/bjd.19163. Epub 2020 Jun 10.
4
Chilblain-like lesions during COVID-19 epidemic: a preliminary study on 63 patients.新冠疫情期间的冻疮样病变:63例患者的初步研究
J Eur Acad Dermatol Venereol. 2020 Jul;34(7):e291-e293. doi: 10.1111/jdv.16526. Epub 2020 May 15.
5
Acral cutaneous lesions in the time of COVID-19.2019冠状病毒病时期的肢端皮肤病变
J Eur Acad Dermatol Venereol. 2020 Aug;34(8):e346-e347. doi: 10.1111/jdv.16533. Epub 2020 May 27.
6
Alert for non-respiratory symptoms of coronavirus disease 2019 patients in epidemic period: A case report of familial cluster with three asymptomatic COVID-19 patients.警惕 2019 年冠状病毒病患者在流行期间的非呼吸症状:一家三口均为无症状 COVID-19 患者的聚集性病例报告。
J Med Virol. 2021 Jan;93(1):518-521. doi: 10.1002/jmv.25776. Epub 2020 Sep 28.
7
A Novel Coronavirus from Patients with Pneumonia in China, 2019.2019 年中国肺炎患者中的一种新型冠状病毒。
N Engl J Med. 2020 Feb 20;382(8):727-733. doi: 10.1056/NEJMoa2001017. Epub 2020 Jan 24.
8
Aicardi-Goutières syndrome and the type I interferonopathies.Aicardi-Goutières 综合征与Ⅰ型干扰素病。
Nat Rev Immunol. 2015 Jul;15(7):429-40. doi: 10.1038/nri3850. Epub 2015 Jun 5.
9
Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study.干扰素相关生物标志物在 TREX1、RNASEH2A、RNASEH2B、RNASEH2C、SAMHD1 和 ADAR 基因突变相关的 Aicardi-Goutières 综合征中的评估:病例对照研究。
Lancet Neurol. 2013 Dec;12(12):1159-69. doi: 10.1016/S1474-4422(13)70258-8. Epub 2013 Oct 30.

COVID-19 and outbreak of chilblains: are they related?

作者信息

Lesort C, Kanitakis J, Villani A, Ducroux E, Bouschon P, Fattouh K, Bensaid B, Danset M, Jullien D

机构信息

Dermatology Department, Edouard Herriot Hospital, Hospices Civils de Lyon, Université Claude Bernard Lyon I, Lyon, France.

出版信息

J Eur Acad Dermatol Venereol. 2020 Dec;34(12):e757-e758. doi: 10.1111/jdv.16779. Epub 2020 Jul 21.

DOI:10.1111/jdv.16779
PMID:32594575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7361424/
Abstract
摘要