Zhao D, Qin H L, Li N
Department of Colorectal Disease Specialty, Intestinal Microecology Diagnosis and Treatment Center, the Tenth People's Hospital, Tongji University, Shanghai 200072, China.
Department of Colorectal Disease Specialty, Intestinal Microecology Diagnosis and Treatment Center, the Tenth People's Hospital, Tongji University, Shanghai 200072, China; Department of Gastrointestinal Surgery, the Tenth People's Hospital, Institute of Intestinal Diseases, Tongji University, Shanghai 200072, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2020 Jul 10;23(Z1):38-44. doi: 10.3760/cma.j.cn.441530-20200414-00205.
Inflammatory bowel disease (IBD) is a group of chronic, recurrent, and inflammatory intestinal diseases. At present, it is believed that the destruction of intestinal homeostasis may be the cause of the onset and progression of IBD. Under normal circumstances, the maintenance of intestinal homeostasis depends on the balance among the intestinal microbes, the intestinal mucosal barrier, and the immune system. Accordingly, the treatment strategy for IBD must take into account micro-ecological reconstruction, immune regulation and intestinal barrier function recovery. Because different patients have different responses to incentives, different treatments, or those at different stages of the disease course show different disease behaviors, multidisciplinary collaboration seems quite necessary. This article aims to introduce a five-in-one integrated treatment strategy, including microecological treatment, immunotherapy, enteral nutrition, interventional therapy, and surgical treatment.
炎症性肠病（IBD）是一组慢性、复发性炎症性肠道疾病。目前认为，肠道稳态的破坏可能是IBD发病和进展的原因。正常情况下，肠道稳态的维持依赖于肠道微生物、肠道黏膜屏障和免疫系统之间的平衡。因此，IBD的治疗策略必须考虑微生态重建、免疫调节和肠道屏障功能恢复。由于不同患者对刺激的反应不同，不同的治疗方法，或疾病进程不同阶段的患者表现出不同的疾病行为，多学科协作显得十分必要。本文旨在介绍一种五合一的综合治疗策略，包括微生态治疗、免疫治疗、肠内营养、介入治疗和手术治疗。
