Atılgan Cemile Üçgül, Şendül Selam Yekta, Kösekahya Pınar, Çağlayan Mehtap, Alkan Alpaslan, Güven Dilek, Yılmazbaş Pelin
Department of Ophthalmology, Ulucanlar Eye Training and Research Hospital, Altindag, Ankara, Turkey.
Department of Ophthalmology, Şişli Etfal Training and Research Hospital, İstanbul, Turkey.
Sisli Etfal Hastan Tip Bul. 2018 Mar 21;52(1):26-30. doi: 10.14744/SEMB.2017.07269. eCollection 2018.
The aim of this study was to evaluate the neutrophil-to-lymphocyte ratio (NLR) and the mean platelet volume (MPV) in patients with active thyroid orbitopathy (TO) and to compare it with that of both healthy subjects and patients with inactive TO.
Twenty patients with active TO (Group 1), 25 patients with inactive TO (Group 2), and 35 age- and sex-matched healthy subjects (Group 3) were included in this study. Patients with other systemic and ocular diseases, patients with a history of intraocular or orbital surgery, and patients using systemic drugs were excluded. The VISA (vision, inflammation, strabismus, appearance) classification scheme was used to discriminate between active and inactive TO. The neutrophil and lymphocyte counts and the MPV of all participants were recorded. The NLR was calculated by dividing the neutrophil count by the lymphocyte count, and the result was compared between groups. The optimal cut-off value was determined for NLR and MPV and the data were compared with a one-way analysis of variance test and the 'Bonferroni post-test.
The mean age was 45.4±13.4, 41.0±13.7, and 42.6±14.4 years in Group 1, 2, and 3, respectively (p=0.68). The NLR was 2.11 in Group 1, 1.56 in Group 2, and 1.47 in Group 3 (p=0.03). The 'Bonferroni post-test revealed a difference between Group 1 and Group 2 (p=0.01) and between Group 1 and Group 3 (p<0.001). The MPV was 10.76 fL in Group 1, 9.94 fL in Group 2, and 8.19 fL in Group 3 (p<0.001). The results of the 'Bonferroni post-test showed a difference between Group 1 and Group 2 (p=0.04), between Group 1 and Group 3 (p<0.001), and between Group 2 and Group 3 (p<0.001). The mean cut-off value obtained from receiver operating characteristic (ROC) analysis of NLR was 1.69 (sensitivity: 72%; specificity: 66%). The mean cut-off value obtained from ROC analysis of MPV was 9.95 (sensitivity: 63%; specificity: 66%).
High NLR and MPV values may be indicative of active inflammation in patients with TO."
本研究旨在评估活动性甲状腺眼病（TO）患者的中性粒细胞与淋巴细胞比值（NLR）和平均血小板体积（MPV），并将其与健康受试者及非活动性TO患者进行比较。
本研究纳入了20例活动性TO患者（第1组）、25例非活动性TO患者（第2组）和35例年龄及性别匹配的健康受试者（第3组）。排除患有其他全身和眼部疾病、有眼内或眼眶手术史以及正在使用全身药物的患者。采用VISA（视力、炎症、斜视、外观）分类方案区分活动性和非活动性TO。记录所有参与者的中性粒细胞和淋巴细胞计数以及MPV。通过中性粒细胞计数除以淋巴细胞计数计算NLR，并在组间比较结果。确定NLR和MPV的最佳临界值，并采用单因素方差分析和“Bonferroni事后检验”对数据进行比较。
第1组、第2组和第3组的平均年龄分别为45.4±13.4岁、41.0±13.7岁和42.6±14.4岁（p=0.68）。第1组的NLR为2.11，第2组为1.56，第3组为1.47（p=0.03）。Bonferroni事后检验显示第1组和第2组之间存在差异（p=0.01），第1组和第3组之间存在差异（p<0.001）。第1组的MPV为10.76 fL，第2组为9.94 fL，第3组为8.19 fL（p<0.001）。Bonferroni事后检验结果显示第1组和第2组之间存在差异（p=0.04），第1组和第3组之间存在差异（p<0.001），第2组和第3组之间存在差异（p<0.001）。NLR的受试者工作特征（ROC）分析得出的平均临界值为1.69（敏感性：72%；特异性：66%）。MPV的ROC分析得出的平均临界值为9.95（敏感性：63%；特异性：66%）。
高NLR和MPV值可能表明TO患者存在活动性炎症。
