Talmac Merve Aldikactioglu, Ciftpinar Tolga, Ozdemir Merve Sam, Yardimci Aytul Hande, Gunay Izel, Kocadal Nilufer Cetinkaya
Department of Gynecological Oncology, University of Health Sciences Türkiye, Basaksehir Cam and Sakura City Hospital, Istanbul, Türkiye.
Department of Radiology, University of Health Sciences Türkiye, Basaksehir Cam and Sakura City Hospital, Istanbul, Türkiye.
Sisli Etfal Hastan Tip Bul. 2023 Sep 29;57(3):326-331. doi: 10.14744/SEMB.2023.47529. eCollection 2023.
Evaluate the effectiveness of magnetic resonance imaging (MRI), blood parameters, and tumor markers to determine the role of objective criteria in distinguishing malignant, borderline, and benign masses and to minimize unnecessary surgical interventions by reducing interpretation differences.
The histopathological and clinical-laboratory results of the patients who underwent surgery for the initial diagnosis and whose ovarian masses were confirmed were retrospectively reviewed. Between groups, age, cancer antigen 125, mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), the presence of ascites, the ovarian-adnexal reporting and data system MRI scores, mass characteristics, and lymphocyte count were compared.
The study comprised a total of 191 patients. These patients were categorized into three groups: Benign (n=113), borderline (n=26), and malignant (n=52). No noteworthy correlation was detected between the unilocular or multilocular nature of solid, cystic, or mixed masses and the rates of NLR, PLR, or MPV. However, a notable correlation was identified between NLR and the presence of acidity (p=0.003). In ovarian cancer patients, there was no significant difference in NLR and MPV between malignant epithelial and malignant sex cord-stromal types (p>0.05), whereas a significant difference emerged in the PLR ratio (p=0.013).
In ovarian masses with malignant potential, laboratory parameters such as NLR and PLR can guide the diagnosis process. In the future, various studies such as the development of different tests, markers, and imaging methods, the use of blood tests such as NLR, PLR, and MPV in cancer diagnosis will be possible. The results of these studies may contribute to the development of new methods for the diagnosis of ovarian cancer and the improvement of treatment protocols.
评估磁共振成像（MRI）、血液参数和肿瘤标志物在确定客观标准以区分恶性、交界性和良性肿块中的作用，并通过减少解读差异来尽量减少不必要的手术干预。
回顾性分析因初步诊断接受手术且卵巢肿块得到确诊的患者的组织病理学和临床实验室结果。比较各组之间的年龄、癌抗原125、平均血小板体积（MPV）、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、腹水情况、卵巢附件报告和数据系统MRI评分、肿块特征以及淋巴细胞计数。
该研究共纳入191例患者。这些患者被分为三组：良性（n = 113）、交界性（n = 26）和恶性（n = 52）。实性、囊性或混合性肿块的单房或多房性质与NLR、PLR或MPV的比率之间未发现显著相关性。然而，NLR与酸度存在显著相关性（p = 0.003）。在卵巢癌患者中，恶性上皮型和恶性性索间质型之间的NLR和MPV无显著差异（p>0.05），而PLR比率存在显著差异（p = 0.013）。
在具有恶性潜能的卵巢肿块中，NLR和PLR等实验室参数可指导诊断过程。未来，开展不同检测、标志物和成像方法的研究，以及将NLR、PLR和MPV等血液检测用于癌症诊断将成为可能。这些研究结果可能有助于开发卵巢癌诊断的新方法并改进治疗方案。
