Dursun Ayhan, Ozturk Sultan, Yucel Hasan, Ozec Ayse Vural, Dursun Feyza Gulac, Toker Mustafa Ilker, Erdogan Haydar, Arici Mustafa Kemal, Topalkara Aysen
1 Department of Ophthalmology, Cumhuriyet University School of Medicine, Sivas - Turkey.
Eur J Ophthalmol. 2015 Jul-Aug;25(4):343-6. doi: 10.5301/ejo.5000570. Epub 2015 Jan 27.
To evaluate the association between neutrophil/lymphocyte ratio (NLR) and the development of retinal vein occlusion (RVO).
Forty patients were included in the study. Forty age- and sex-matched healthy volunteers were recruited as the control group. The RVO diagnosis was made clinically, based on the findings of fundus examination. The NLR and file records of the patients and the control group were compared.
The mean age of patients was 64 ± 12 years. Neutrophil levels were higher in RVO patients compared to the control subjects (5.1 ± 1.9 vs 3.6 ± 1.0, p<0.001). Lymphocyte levels were lower in RVO patients compared with the control subjects (2.0 ± 0.7 vs 2.6 ± 0.9, p = 0.005). The NLR was significantly higher in RVO patients compared with the control subjects (3.0 ± 2.7 vs 1.5 ± 0.3, p<0.001). According to the receiver operator characteristics curve analysis, the optimal cutoff value of NLR to predict RVO was >1.89, with 72.5% sensitivity and 100% specificity.
The current study demonstrated that higher NLR was associated with the development of RVO. The NLR may be used as a predictive tool for identifying risk for RVO.
评估中性粒细胞/淋巴细胞比值（NLR）与视网膜静脉阻塞（RVO）发生之间的关联。
本研究纳入40例患者。招募40名年龄和性别匹配的健康志愿者作为对照组。根据眼底检查结果进行RVO的临床诊断。比较患者和对照组的NLR及档案记录。
患者的平均年龄为64±12岁。与对照组相比，RVO患者的中性粒细胞水平更高（5.1±1.9对3.6±1.0，p<0.001）。与对照组相比，RVO患者的淋巴细胞水平更低（2.0±0.7对2.6±0.9，p = 0.005）。与对照组相比，RVO患者的NLR显著更高（3.0±2.7对1.5±0.3，p<0.001）。根据受试者工作特征曲线分析，预测RVO的NLR最佳截断值>1.89，敏感性为72.5%，特异性为100%。
本研究表明，较高的NLR与RVO的发生有关。NLR可作为识别RVO风险的预测工具。
