Sabrah Alaa H A, Al-Asmar Ayah A, Alsoleihat Firas, Al-Zer Heba
Department of Conservative Dentistry, The University of Jordan, Amman, Jordan.
J Dent Sci. 2020 Jun;15(2):181-185. doi: 10.1016/j.jds.2019.06.005. Epub 2019 Dec 26.
BACKGROUND/PURPOSE: Triple antibiotic paste (TAP) has been successfully used in revascularization procedure. However, one of the problems associated with TAP use is teeth discoloration, which is attributed to the presence of minocycline constituent. The aim of this study is to investigate the discoloration effect of different concentrations of triple (TAP) and double (DAP) antibiotics pastes on root dentine.
Sterilized dentine specimens (4 × 4 × 1) were prepared, and randomly assigned to 5 groups; 1000 mg/mL of Triple antibiotic paste (TAP), 1000 mg/mL of Double antibiotic paste (DAP), 1 mg/mL of TAP in Methylcellulose gel (MTAP), 1 mg/mL of DAP in Methylcellulose gel (MDAP), and distilled water control groups (n = 12). The assigned treatment was applied for 14 days. The CIE Lab calorimetric parameters were measured for all dentine specimens using a Chroma meter. One-way ANOVA and multiple comparisons were used for statistical analyses (p < 0.05). ΔE for the different treatments as compared to distilled water group was calculated.
TAP and MTAP groups significantly affects the L* values of the root dentine (p < 0.05). ΔE change was noticeable between TAP and MTAP compared to the distilled water group.
The incorporation of minocycline in TAP medicaments, even in low concentrations, can still provoke a noticeable tooth discoloration.
背景/目的：三联抗生素糊剂（TAP）已成功应用于牙髓血管再生术。然而，使用TAP的相关问题之一是牙齿变色，这归因于米诺环素成分的存在。本研究的目的是调查不同浓度的三联（TAP）和双联（DAP）抗生素糊剂对牙根牙本质的变色影响。
制备灭菌牙本质标本（4×4×1），并随机分为5组；1000mg/mL三联抗生素糊剂（TAP）、1000mg/mL双联抗生素糊剂（DAP）、1mg/mL TAP溶于甲基纤维素凝胶（MTAP）、1mg/mL DAP溶于甲基纤维素凝胶（MDAP）以及蒸馏水对照组（n = 12）。将指定的处理应用14天。使用色度计测量所有牙本质标本的CIE Lab颜色参数。采用单因素方差分析和多重比较进行统计分析（p < 0.05）。计算与蒸馏水组相比不同处理的ΔE值。
TAP组和MTAP组显著影响牙根牙本质的L*值（p < 0.05）。与蒸馏水组相比，TAP组和MTAP组之间的ΔE变化明显。
即使是低浓度，TAP药物中加入米诺环素仍可引起明显的牙齿变色。
