The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430079, China.
Department of Anesthesiology, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430079, China.
Biomed Res Int. 2020 Jun 2;2020:6130162. doi: 10.1155/2020/6130162. eCollection 2020.
Dexmedetomidine refers to an -adrenergic receptor agonist causing potent sedative, analgesic, and minimal respiratory depression compared with alternative drugs. The present study was aimed at comparing the efficaciousness and safety of midazolam and dexmedetomidine as sedatives for dental implantation. We recruited 60 patients belonging to group I or II of the American Society of Anesthesiologists (ASA) and treated them with either midazolam or dexmedetomidine in a random manner. Patients' duration of analgesia after surgery, surgeon and patient degrees of satisfaction, Observer's Assessment of Alertness/Sedation Scale (OAAS) scores after drug administration, visual analogue scale (VAS) pain scores, and vital signs were recorded variables. Patients administered dexmedetomidine had significantly lower OAAS scores than those administered midazolam ( < 0.05). Patients administrated dexmedetomidine had a significantly longer analgesia duration after the surgical procedure than those administered midazolam, and the difference was statistically significant ( < 0.05). Dexmedetomidine had a significantly larger number of surgeons satisfied with the level of sedation/analgesia than midazolam ( < 0.05). Accordingly, it is considered that dexmedetomidine can achieve better postoperative analgesia, surgeon satisfaction, and sedation than midazolam.
右美托咪定是一种 - 肾上腺素能受体激动剂，与其他药物相比，具有较强的镇静、镇痛作用，且呼吸抑制作用较轻。本研究旨在比较咪达唑仑和右美托咪定作为牙科植入镇静剂的疗效和安全性。我们招募了 60 名美国麻醉医师学会（ASA）I 或 II 级的患者，并以随机方式对他们进行咪达唑仑或右美托咪定治疗。记录了患者术后镇痛时间、术者和患者满意度、用药后警觉/镇静评分（OAAS）、视觉模拟评分（VAS）疼痛评分和生命体征等变量。给予右美托咪定的患者 OAAS 评分明显低于给予咪达唑仑的患者（<0.05）。给予右美托咪定的患者术后镇痛时间明显长于给予咪达唑仑的患者，差异有统计学意义（<0.05）。给予右美托咪定的术者对镇静/镇痛水平的满意度明显高于给予咪达唑仑的术者（<0.05）。因此，认为右美托咪定可获得比咪达唑仑更好的术后镇痛、术者满意度和镇静效果。
