Developmental Epileptology, Institute of Physiology of the Czech Academy of Science, Prague, Czech Republic.
Epilepsia Open. 2023 May;8 Suppl 1(Suppl 1):S90-S109. doi: 10.1002/epi4.12664. Epub 2022 Nov 9.
Status epilepticus (SE) is the most common neurologic emergency in children. Both clinical and laboratory studies have demonstrated that SE in early life can cause brain damage and permanent behavioral abnormalities, trigger epileptogenesis, and interfere with normal brain development. In experimental rodent models, the consequences of seizures are dependent upon age, the model used, and seizure duration. In studies involving neonatal and infantile animals, the model used, experimental design, conditions during the experiment, and manipulation of animals can significantly affect the course of the experiments as well as the results obtained. Standardization of laboratory approaches, harmonization of scientific methodology, and improvement in data collection can improve the comparability of data among laboratories.
癫痫持续状态（SE）是儿童中最常见的神经急症。临床和实验室研究都表明，生命早期的 SE 可导致脑损伤和永久性行为异常，引发癫痫发生，并干扰正常的大脑发育。在实验性啮齿动物模型中，癫痫发作的后果取决于年龄、所使用的模型和发作持续时间。在涉及新生和婴儿动物的研究中，所使用的模型、实验设计、实验期间的条件以及对动物的操作会极大地影响实验过程以及获得的结果。实验室方法的标准化、科学方法的协调以及数据收集的改进可以提高实验室之间数据的可比性。
