受贻贝启发在PolyJet材料上辅助磷灰石矿化用于人工骨支架。
The mussel-inspired assisted apatite mineralized on PolyJet material for artificial bone scaffold.
作者信息
Chen Yi-Wen, Fang Hsin-Yuan, Shie Ming-You, Shen Yu-Fang
机构信息
Three-dimensional Printing Medical Research Center, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
出版信息
Int J Bioprint. 2019 Jul 11;5(2):197. doi: 10.18063/ijb.v5i2.197. eCollection 2019.
Abstract
With the development of three-dimensional (3D) printing, many commercial 3D printing materials have been applied in the fields of biomedicine and medical. MED610 is a clear, biocompatible PolyJet material that is medically certified for bodily contact. In this study, the polydopamine (PDA)/hydroxyapatite (HA) coating was added to the printed MED610 objects to evaluate its physical properties, cell proliferation, cell morphology, and alkaline phosphatase expression level. The results show that the PDA/HA coating helps printed objects to enhance the hardness, biocompatibility, and osteogenic differentiation potential. We expect that PDA/HA coatings contribute to the applicability of MED610 in biomedical and medical applications.
摘要
随着三维（3D）打印技术的发展，许多商用3D打印材料已应用于生物医学和医疗领域。MED610是一种透明的、具有生物相容性的PolyJet材料，已通过医疗认证可用于身体接触。在本研究中，将聚多巴胺（PDA）/羟基磷灰石（HA）涂层添加到打印的MED610物体上，以评估其物理性能、细胞增殖、细胞形态和碱性磷酸酶表达水平。结果表明，PDA/HA涂层有助于提高打印物体的硬度、生物相容性和成骨分化潜力。我们期望PDA/HA涂层有助于MED610在生物医学和医疗应用中的适用性。
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