Geramizadeh Bita
Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran.
Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Clin Pathol. 2020 Jun 15;13:2632010X20925045. doi: 10.1177/2632010X20925045. eCollection 2020 Jan-Dec.
Cholangiocarcinoma (CCA) develops through multistep carcinogenesis. During the past decades, 2 precursors have been proved to evolve to CCA. The 2 main precursor lesions of CCA are biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct. It is an interesting and relatively novel entity for the hepatobiliary surgeons, radiologists, oncologists, and pathologists. It worth being familiar with these 2 entities for better communication between pathologists, oncologists, and surgeons to improve the treatment and follow-up of these lesions, which can definitely decrease their evolvement to CCA as an aggressive, poor prognostic, and life-threatening cancer. In this narrative review, I collected and discussed all published studies about these 2 precursor lesions of CCA including radiologic, clinical, and pathological manifestation.
胆管癌（CCA）通过多步骤致癌过程发展而来。在过去几十年中，已证实有2种前体可演变为CCA。CCA的2种主要前体病变是胆管上皮内瘤变和胆管内乳头状肿瘤。对于肝胆外科医生、放射科医生、肿瘤学家和病理学家来说，这是一个有趣且相对新颖的实体。熟悉这2种实体对于病理学家、肿瘤学家和外科医生之间更好地沟通以改善这些病变的治疗和随访非常有价值，这肯定可以减少它们演变为具有侵袭性、预后不良且危及生命的癌症CCA。在这篇叙述性综述中，我收集并讨论了所有已发表的关于CCA这2种前体病变的研究，包括其放射学、临床和病理学表现。
