Rupprecht T, Wenzel D, Michalk D
Kinderklinik mit Poliklinik, Universität Erlangen-Nünberg.
Monatsschr Kinderheilkd. 1988 Mar;136(3):143-5.
A 17 year old girl with chronic relapsing pancreatitis since the age of 11 developed focal seizures, leukopenia, anemia and thrombozytopenia, signs suggesting lupus erythematodes. All immunologic investigations, including tests for Anti-DNS-Antibodies were negative, however. Therapy with prednisone and azathioprine resulted in clinical remission. Reduction of the immunosuppression lead to a severe crisis, which was controlled by plasmaseparation and cyclophosphamide. Subsequent analysis of circulating immune complexes revealed bound anti-DNS-antibodies.
一名自11岁起患有慢性复发性胰腺炎的17岁女孩出现局灶性癫痫发作、白细胞减少、贫血和血小板减少，这些体征提示红斑狼疮。然而，所有免疫检查，包括抗双链DNA抗体检测均为阴性。泼尼松和硫唑嘌呤治疗使临床症状缓解。免疫抑制的减少导致了严重危机，通过血浆置换和环磷酰胺得以控制。随后对循环免疫复合物的分析发现了结合的抗双链DNA抗体。
