Brown M, McDonnell M K, Menton D N
Program in Physical Therapy, Washington University Medical School, St. Louis, MO 63110.
Phys Ther. 1988 Jun;68(6):955-60. doi: 10.1093/ptj/68.6.955.
The purpose of this study was to determine the effects of high voltage monophasic pulsed electrical stimulation on wound healing using positive polarity. Forty-four rabbits were assigned to experimental or control groups and followed for four or seven days. We classified the groups as Exp4, Con4, Exp7, and Con7, respectively. Each animal was anesthetized, and a full-thickness incision, 3.5-cm long, was made on its back. After 24 hours, the Exp4 and Exp7 rabbits received high voltage electrical stimulation for two hours twice daily. Wound closure for the Exp4 rabbits (50%) was significantly less than that of the Con4 rabbits (78%). After seven days, however, the Exp7 and Con7 rabbits had similar wound-closure values (80% and 82%, respectively). Tensile-strength values for the control and experimental animals were comparable at both time periods. Histologic examination of the wounds suggested a more rapid rate of epithelization between the Exp4 and Exp7 rabbits compared with the Con4 and Con7 rabbits. The results of this study are inconclusive, but may indicate that positive-polarity stimulation enhanced wound closure between four and seven days of treatment.
本研究的目的是确定使用正极性的高压单相脉冲电刺激对伤口愈合的影响。44只兔子被分配到实验组或对照组，并分别观察4天或7天。我们将这些组分别分类为Exp4、Con4、Exp7和Con7。每只动物均麻醉后，在其背部做一个3.5厘米长的全层切口。24小时后，Exp4和Exp7组的兔子每天接受两次高压电刺激，每次两小时。Exp4组兔子的伤口闭合率（50%）显著低于Con4组兔子（78%）。然而，7天后，Exp7和Con7组兔子的伤口闭合值相似（分别为80%和82%）。在两个时间段，对照组和实验组动物的拉伸强度值相当。伤口的组织学检查表明，与Con4和Con7组兔子相比，Exp4和Exp7组兔子的上皮形成速度更快。本研究结果尚无定论，但可能表明正极性刺激在治疗4至7天内可促进伤口闭合。
