Brown M, Gogia P P
Phys Ther. 1987 May;67(5):662-7. doi: 10.1093/ptj/67.5.662.
The primary purpose of this study was to determine whether high voltage stimulation (HVS) enhances wound healing. Forty female rabbits were assigned to experimental or control groups and followed for four or seven days. We classified the groups as Exp4, Con4, Exp7, and Con7, respectively. Each animal was anesthetized, and a full-thickness incision, 3.5-cm long, was made on its back. After 24 hours, Exp4 and Exp7 rabbits received HVS with a negative polarity for two hours twice daily. Although tensile-strength values were 36% higher for Exp4 rabbits than for Con4 rabbits, no significant differences in tensile strength or percentage of wound closure existed between the two groups. After seven days, Con7 rabbits had a higher percentage of wound closure and significantly greater tensile-strength measures than Exp7 rabbits. Histologic examination of the wounds did not provide clear-cut evidence of differences between the experimental and control groups. Results suggest that 1) HVS did not significantly improve wound healing for Exp4 rabbits and 2) HVS as given, may have hampered the healing process for Exp7 rabbits.
本研究的主要目的是确定高压刺激（HVS）是否能促进伤口愈合。40只雌性兔子被分为实验组或对照组，并分别观察4天或7天。我们将这些组分别归类为Exp4、Con4、Exp7和Con7。每只动物均进行麻醉，然后在其背部制作一个3.5厘米长的全层切口。24小时后，Exp4和Exp7组的兔子每天接受两次负极性的高压刺激，每次两小时。虽然Exp4组兔子的抗张强度值比Con4组兔子高36%，但两组之间在抗张强度或伤口闭合百分比方面没有显著差异。7天后，Con7组兔子的伤口闭合百分比更高，抗张强度测量值也明显高于Exp7组兔子。伤口的组织学检查没有提供实验组和对照组之间存在差异的确切证据。结果表明：1）高压刺激对Exp4组兔子的伤口愈合没有显著改善；2）所采用的高压刺激可能阻碍了Exp7组兔子的愈合过程。
