Department of Pediatrics, Division of Allergy, Asthma, and Rheumatology, Linkuo Chang Gung Memorial Hospital, Taoyuan, Taiwan.
College of Medicine, Chang Gung University, Taoyuan, Taiwan.
J Asthma. 2021 Oct;58(10):1278-1284. doi: 10.1080/02770903.2020.1788075. Epub 2020 Sep 21.
Air pollution is associated with the prevalence of respiratory diseases. This study aimed to evaluate the impacts of outdoor air pollutants and indoor 1 ( 1) exposure on levels of fractional exhaled nitric oxide (FeNO), exhaled breath condensate (EBC) pH, and pulmonary function in atopic children.
This study recruited 59 atopic mild-to-moderate asthmatic children and 23 atopic non-asthmatic children. Data on personal characteristics, FeNO, EBC pH, and pulmonary function were collected. Group 1 allergens of 1 were measured on the tops of mattresses and on bedroom floors in the children's homes, and outdoor air pollutant concentrations were estimated from air quality monitoring stations, using the ordinary kriging method.
Exposure levels of outdoor air pollutants, except for particulate matter (PM), for the recruited children met outdoor air quality standards set by the Taiwan Environmental Protection Agency. The lag effect of outdoor PM exposure was negatively associated with the forced expiratory volume in one second (FEV) [(Lag 1: =-0.771, = 0.028), and O (Lag 1-7: =-2.02, = 0.04, Lag 1-28: =-3.213, = 0.029)]. Median pulmonary function parameters differed significantly in forced vital capacity (FVC) ( = 0.004) and FEV ( = 0.024) values between atopic asthmatic and non-asthmatic children. No association was found between the FeNO/EBC pH level and exposure to 1 allergen and air pollutants in the recruited children.
Outdoor PM and O exposure was associated with reduction in FEV in atopic asthmatic and non-asthmatic children.
空气污染与呼吸道疾病的流行有关。本研究旨在评估户外空气污染物和室内 1 暴露对特应性儿童呼出气一氧化氮（FeNO）、呼气冷凝液（EBC）pH 值和肺功能的影响。
本研究招募了 59 名特应性轻中度哮喘儿童和 23 名特应性非哮喘儿童。收集个人特征、FeNO、EBC pH 值和肺功能数据。测量了儿童家中床垫顶部和卧室地板上的 1 组过敏原，使用普通克里金法从空气质量监测站估算了室外空气污染物浓度。
所招募儿童的室外空气污染物暴露水平，除颗粒物（PM）外，均符合台湾环境保护署制定的室外空气质量标准。室外 PM 暴露的滞后效应与 1 秒用力呼气量（FEV）呈负相关[（Lag 1：=-0.771，=0.028），和 O（Lag 1-7：=-2.02，=0.04，Lag 1-28：=-3.213，=0.029）]。特应性哮喘和非哮喘儿童的用力肺活量（FVC）（=0.004）和 FEV（=0.024）的中位数肺功能参数存在显著差异。在本研究中，未发现 FeNO/EBC pH 值水平与 1 过敏原和空气污染物暴露之间存在关联。
户外 PM 和 O 暴露与特应性哮喘和非哮喘儿童的 FEV 降低有关。
