Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shanxi 710071, China.
Department of Radiology, School of Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai 200011, China.
Dalton Trans. 2020 Jul 17;49(27):9444-9453. doi: 10.1039/d0dt02042g.
In this research, a pH-sensitive degradable nanoprobe was designed by combining hydrophobic rare earth nanoparticles with biocompatible mPEG-PLGA nanomicelles for near infrared II (NIR-II) imaging-guided anti-tumor chemotherapy. The as-synthesized nanoprobes (about 300 nm) with a highly enhanced permeability and retention (EPR) effect show great potential in the diagnosis of solid tumors, providing new prospects for clinical tumor diagnosis. Then, the degradable composite probes increase the imaging sensitivity of the probe and allow for the slow release of the internal anti-tumor drugs, reducing the loss of the drug during delivery. Finally, ultra-small rare earth nanoparticles (about 6 nm) can be excreted after hydrolysis of the composite probe to reduce the enrichment of the inorganic nanoparticles in vivo. Thus, this degradable NIR-II imaging probe based on a polymer-lanthanide composite could be a promising candidate for preclinical cancer chemotherapy and surgery navigation under a single 808 nm laser.
在这项研究中，通过将疏水性稀土纳米粒子与生物相容性的 mPEG-PLGA 纳米胶束结合，设计了一种 pH 敏感的可降解纳米探针，用于近红外二区（NIR-II）成像引导的抗肿瘤化学疗法。所合成的纳米探针（约 300nm）具有高增强渗透性和保留（EPR）效应，在实体瘤的诊断中具有很大的潜力，为临床肿瘤诊断提供了新的前景。然后，可降解的复合探针增加了探针的成像灵敏度，并允许内部抗肿瘤药物缓慢释放，减少了在输送过程中药物的损失。最后，复合探针水解后可排出超小的稀土纳米粒子（约 6nm），以减少体内无机纳米粒子的富集。因此，这种基于聚合物-镧系元素复合材料的可降解 NIR-II 成像探针有望成为单一 808nm 激光下临床癌症化疗和手术导航的候选物。
