Department of Oral and Maxillofacial Surgery, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
J Interferon Cytokine Res. 2020 Jul;40(7):357-369. doi: 10.1089/jir.2019.0145. Epub 2020 Jun 27.
The mechanisms of genetic alteration are checked to be responsible for the oral cancer incidence. Herein, this meta-analysis aimed to assess the association between -1082A/G, -592A/C, and -819T/C polymorphisms of () and susceptibility to oral cancer. We systematically searched the PubMed, Web of Science, Cochrane Library, and Scopus databases until May 2019 to find the studies reporting the association between the IL-10 polymorphisms and the oral cancer risk. Rev Man 5.3 software was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs). The CMA (version 2.0) software showed the results of publication bias. In addition, SPSS (version 22.0) was used for meta-regression analysis. Out of 8 studies included in this meta-analysis, 7, 6, and 5 studies reported -1082A/G, -592A/C, and -819T/C polymorphisms, respectively. The pooled ORs of the allele, homozygote, heterozygote, dominant, and recessive models were 1.64 (95% CI: 1.26-2.13), 2.99 (95% CI: 1.32-6.79), 1.64 (95% CI: 1.16-2.33), 1.77 (95% CI: 1.25-2.49), and 2.44 (95% CI: 1.21-4.92), respectively, showing a significant association for -1082A/G polymorphism, but not for -592A/C, and -819T/C polymorphisms with the risk of oral cancer. However, subgroup analysis showed an association for -592A/C polymorphisms, Caucasian ethnicity, and hospital-based controls. In summary, the findings of this meta-analysis illustrated an elevated risk of oral cancer related to -1082A/G polymorphism, but there was no association between -592A/C and -819C/T polymorphisms and the risk of oral cancer.
遗传改变的机制被认为是导致口腔癌发生的原因。本研究旨在评估白细胞介素 10（）-1082A/G、-592A/C 和-819T/C 多态性与口腔癌易感性之间的关系。我们系统地检索了 PubMed、Web of Science、Cochrane Library 和 Scopus 数据库，以查找报道白细胞介素 10 多态性与口腔癌风险之间关系的研究。RevMan 5.3 软件用于计算比值比（OR）和 95%置信区间（CI）。CMA（版本 2.0）软件显示了发表偏倚的结果。此外，SPSS（版本 22.0）用于进行荟萃回归分析。在纳入本荟萃分析的 8 项研究中，分别有 7、6 和 5 项研究报道了 -1082A/G、-592A/C 和-819T/C 多态性。等位基因、纯合子、杂合子、显性和隐性模型的合并 OR 分别为 1.64（95%CI：1.26-2.13）、2.99（95%CI：1.32-6.79）、1.64（95%CI：1.16-2.33）、1.77（95%CI：1.25-2.49）和 2.44（95%CI：1.21-4.92），表明 -1082A/G 多态性与口腔癌风险显著相关，但 -592A/C 和-819T/C 多态性与口腔癌风险无关。然而，亚组分析显示 -592A/C 多态性与口腔癌相关，白种人种族和基于医院的对照存在关联。总之，本荟萃分析的结果表明，-1082A/G 多态性与口腔癌风险增加相关，但 -592A/C 和-819T/C 多态性与口腔癌风险之间没有关联。
