Holloway J D, Schocken D D
Department of Internal Medicine, University of South Florida College of Medicine, Tampa 33612.
Am J Med Sci. 1988 May;295(5):424-32. doi: 10.1097/00000441-198805000-00003.
The Coronary Artery Surgery Study (CASS) was a prospective, randomized evaluation of the value of coronary artery bypass grafting compared with medical therapy for stable, mildly symptomatic coronary artery disease. Also, the CASS registry collected clinic information and follow-up data from 24,959 nonconsecutive patients undergoing cardiac catheterization from 1974 to 1979. CASS has had a major impact on current management of the coronary disease patient and represents an important contribution to the cardiovascular knowledge base. Despite the large size and valuable contributions of CASS, its findings have been widely misinterpreted, especially regarding indications for coronary artery bypass surgery. This review examines CASS from the viewpoint of its methodology and some of its many published reports. A full understanding of CASS is requisite to avoid clinical misapplication of the findings of this study.
冠状动脉外科研究（CASS）是一项前瞻性、随机对照评估，对比了冠状动脉搭桥术与药物治疗对稳定型、轻度症状性冠状动脉疾病的价值。此外，CASS注册研究收集了1974年至1979年期间24959例接受心脏导管插入术的非连续患者的临床信息和随访数据。CASS对目前冠心病患者的管理产生了重大影响，是心血管知识库的一项重要贡献。尽管CASS规模庞大且贡献巨大，但其研究结果却被广泛误解，尤其是在冠状动脉搭桥手术的适应症方面。本综述从其方法学及众多已发表报告的角度审视CASS。全面理解CASS对于避免该研究结果在临床中的错误应用是必要的。
