Herregods L, Capiau P, Rolly G, De Sommer M, Donadoni R
Department of Anaesthesia, University Hospital, Ghent, Belgium.
Br J Anaesth. 1988 Apr;60(5):565-9. doi: 10.1093/bja/60.5.565.
Sixty unpremedicated adult patients, undergoing arthroscopy, received propofol 2 mg kg-1 for induction of anaesthesia, before random allocation to three groups receiving one of the following: a continuous infusion of propofol supplemented with nitrous oxide in oxygen (group I); isoflurane and nitrous oxide in oxygen (group II); a continuous infusion of propofol in combination with repeated bolus doses of alfentanil (group III). The results showed no major differences in cardiovascular variables between the groups. Ventilation rate was highest in group II. Early recovery was less smooth and showed slight impairment in group III compared with the other groups. The data suggest that induction of anaesthesia with propofol followed by maintenance with isoflurane or continuous infusion of propofol is preferable for this procedure.
60例未使用术前药的成年患者接受关节镜检查，麻醉诱导时静脉注射丙泊酚2mg/kg，随后随机分为三组，分别接受以下处理之一：丙泊酚持续输注并辅以氧化亚氮-氧气混合气（Ⅰ组）；异氟烷和氧化亚氮-氧气混合气（Ⅱ组）；丙泊酚持续输注并联合重复静脉注射阿芬太尼（Ⅲ组）。结果显示，三组间心血管指标无显著差异。Ⅱ组的通气频率最高。与其他组相比，Ⅲ组的早期苏醒不太平稳且有轻微损害。数据表明，对于该手术，丙泊酚诱导麻醉后用异氟烷维持或丙泊酚持续输注更为可取。
