哪种类型的癌症患者更容易感染 SARS-COX-2：来自荟萃分析和生物信息学分析的证据。
Which type of cancer patients are more susceptible to the SARS-COX-2: Evidence from a meta-analysis and bioinformatics analysis.
机构信息
Weifang Medical University, 261031, Weifang, China.
Department of Oncology, Affiliated Hospital of Weifang Medical University, 261031, Weifang, China.
出版信息
Crit Rev Oncol Hematol. 2020 Sep;153:103032. doi: 10.1016/j.critrevonc.2020.103032. Epub 2020 Jun 15.
OBJECTIVE
Numerous studies have reported that patients with cancer seem to be more likely to be diagnosed with COVID-19. However, it is still unknown the prevalence of different types of cancer in patients with COVID-19. Therefore, this study will explore which type of cancer patients are more susceptible to the SARS-COX-2.
METHODS
Eligible studies were identified by searching several electronic databases for relevant studies published before April 28, 2020. The language was restricted to English or Chinese. The meta-analysis was performed using Stata 12.0. The GEPIA database evaluated the expression of SARS-COX-2 infection key genes in different types of normal and tumor samples.
RESULTS
A total of 6 studies, including 205 patients, were identified to be eligible for this meta-analysis. Among the cancer patients infected by SARS-COX-2, the proportion of patients with the lung, colorectal, breast, esophagus, bladder, pancreatic and cervical cancer were 24.7 %, 20.5 %, 13.0 %, 7.6 %,7.3 %,6.1 %,and 6.0 %, respectively. These findings were also corroborated by the results of the GEPIA database.
CONCLUSION
Compared with other types of cancer, lung cancer and colorectal cancer are more susceptible to SARS-COX-2 infection.
目的
许多研究报告称，癌症患者似乎更容易被诊断为 COVID-19。然而，COVID-19 患者中不同类型癌症的患病率仍不清楚。因此，本研究将探讨哪些类型的癌症患者更容易感染 SARS-COX-2。
方法
通过检索几个电子数据库，检索到 2020 年 4 月 28 日前发表的相关研究，确定符合条件的研究。语言限制为英语或中文。使用 Stata 12.0 进行荟萃分析。GEPIA 数据库评估了 SARS-COX-2 感染关键基因在不同类型正常和肿瘤样本中的表达。
结果
共有 6 项研究，包括 205 名患者，被确定符合本荟萃分析的条件。在感染 SARS-COX-2 的癌症患者中，患有肺癌、结直肠癌、乳腺癌、食管癌、膀胱癌、胰腺癌和宫颈癌的患者比例分别为 24.7%、20.5%、13.0%、7.6%、7.3%、6.1%和 6.0%。GEPIA 数据库的结果也证实了这一发现。
结论
与其他类型的癌症相比，肺癌和结直肠癌更容易感染 SARS-COX-2。
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