Department of Cell Biology, Physiology and Immunology, School of Biology, University of Barcelona, 08028 Barcelona, Spain; Institute of Biomedicine of the University of Barcelona (IBUB), 08028 Barcelona, Spain.
Department of Cell Biology, Physiology and Immunology, School of Biology, University of Barcelona, 08028 Barcelona, Spain; Institute of Biomedicine of the University of Barcelona (IBUB), 08028 Barcelona, Spain.
Curr Opin Pharmacol. 2020 Aug;53:55-65. doi: 10.1016/j.coph.2020.05.001. Epub 2020 Jun 28.
Liver X receptors (LXRs) are transcription factors from the nuclear receptor family that can be pharmacologically activated by high-affinity agonists. LXR activation exerts a combination of metabolic and anti-inflammatory actions that result in the modulation of immune responses and in the amelioration of inflammatory disorders. In addition, LXR agonists modulate the metabolism of infected cells and limit the infectivity and/or growth of several pathogens. This review gives an overview of the recent advances in understanding the complexity of the mechanisms through which the LXR pathway controls inflammation and host-cell pathogen interaction.
肝 X 受体 (LXRs) 是核受体家族的转录因子，可以被高亲和力激动剂药理学激活。LXR 激活发挥代谢和抗炎作用的组合，导致免疫反应的调节和炎症性疾病的改善。此外，LXR 激动剂调节感染细胞的代谢，并限制几种病原体的感染力和/或生长。本综述概述了理解 LXR 途径控制炎症和宿主细胞病原体相互作用的机制复杂性的最新进展。
