Huang Jiawen, Xu Like, Liu Weiru, Lin Chuanquan, Tang Ying, Shen Chuangpeng, Gao Yong
State Key Laboratory of Traditional Chinese Medicine Syndrome, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Int J Mol Sci. 2025 Jun 30;26(13):6345. doi: 10.3390/ijms26136345.
Nuclear receptors are proteins located in the nucleus that are involved in gene transcription and play an important role in regulating metabolism and inflammation. Systemic metabolic abnormalities and chronic inflammation in diabetic patients are associated with gene expression and activity of bile acid metabolism, lipid and carbohydrate metabolism, energy expenditure, and inflammation regulated by nuclear receptors. As a major metabolic organ, the nuclear receptor regulation signal of the liver is the key to regulating the dialog between the liver and other organs. In this review, we discuss the newly discovered role of hepatic nuclear receptor signaling in diabetes metabolism and inflammation and focus on recent advances in drug research targeting nuclear receptors in diabetes, including the use of traditional Chinese medicine.
核受体是位于细胞核内的蛋白质，参与基因转录，在调节代谢和炎症方面发挥重要作用。糖尿病患者的全身代谢异常和慢性炎症与核受体调节的胆汁酸代谢、脂质和碳水化合物代谢、能量消耗及炎症的基因表达和活性相关。作为主要的代谢器官，肝脏的核受体调节信号是调节肝脏与其他器官之间对话的关键。在本综述中，我们讨论了肝脏核受体信号在糖尿病代谢和炎症中新发现的作用，并重点关注糖尿病中靶向核受体的药物研究进展，包括中药的应用。
