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韩国全国队列研究:胸主动脉置换术后机构病例数量与死亡率之间的关联

Association between institutional case volume and mortality following thoracic aorta replacement: a nationwide Korean cohort study.

作者信息

Nam Karam, Jang Eun Jin, Jo Jun Woo, Choi Jae Woong, Lee Minkyoo, Ryu Ho Geol

机构信息

Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Department of Information Statistics, Andong National University, Andong, Gyeongsangbuk-do, Korea.

出版信息

J Cardiothorac Surg. 2020 Jun 29;15(1):156. doi: 10.1186/s13019-020-01204-0.

Abstract

BACKGROUND

The inverse relationship between case volume and postoperative mortality following high-risk surgical procedures have been reported. Thoracic aorta surgery is associated with one of the highest postoperative mortality. The relationship between institutional case volume and postoperative mortality in patients undergoing thoracic aorta replacement surgery was evaluated.

METHODS

All thoracic aorta replacement surgeries performed in Korea between 2009 and 2016 in adult patients were analyzed using an administrative database. Hospitals were divided into low (< 30 cases/year), medium (30-60 cases/year), or high (> 60 cases/year) volume centers depending on the annual average number of thoracic aorta replacement surgeries performed. The impact of case volume on in-hospital mortality was assessed using the logistic regression.

RESULTS

Across 83 hospitals, 4867 cases of thoracic aorta replacement were performed. In-hospital mortality was 8.6% (191/2222), 10.7% (77/717), and 21.9% (422/1928) in high, medium, and low volume centers, respectively. The adjusted risk of in-hospital mortality was significantly higher in medium (odds ratio [OR], 1.56; 95% confidence interval [CI], 1.16-2.11, P = 0.004) and low volume centers (OR, 3.12; 95% CI, 2.54-3.85, P < 0.001) compared to high volume centers.

CONCLUSIONS

Patients who had underwent thoracic aorta replacement surgery in lower volume centers had increased risk of in-hospital mortality after surgery compared to those in higher volume centers. Our results may provide the basis for minimum case volume requirement or regionalization in thoracic aorta replacement surgery for optimal patient outcome.

摘要

背景

高风险手术术后病例数量与死亡率之间的负相关关系已有报道。胸主动脉手术是术后死亡率最高的手术之一。本研究评估了机构病例数量与接受胸主动脉置换手术患者术后死亡率之间的关系。

方法

利用行政数据库分析了2009年至2016年在韩国为成年患者实施的所有胸主动脉置换手术。根据每年胸主动脉置换手术的平均数量,医院被分为低(<30例/年)、中(30 - 60例/年)或高(>60例/年)病例数量中心。采用逻辑回归评估病例数量对住院死亡率的影响。

结果

在83家医院中,共进行了4867例胸主动脉置换手术。高、中、低病例数量中心的住院死亡率分别为8.6%(191/2222)、10.7%(77/717)和21.9%(422/1928)。与高病例数量中心相比,中病例数量中心(比值比[OR],1.56;95%置信区间[CI],1.16 - 2.11,P = 0.004)和低病例数量中心(OR,3.12;95% CI,2.54 - 3.85,P < 0.001)调整后的住院死亡风险显著更高。

结论

与高病例数量中心的患者相比,在低病例数量中心接受胸主动脉置换手术的患者术后住院死亡风险增加。我们的结果可为胸主动脉置换手术的最低病例数量要求或区域化提供依据,以实现最佳患者预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8af/7325263/2d169cf57328/13019_2020_1204_Fig1_HTML.jpg

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