Orthopedic Institute, Department of Orthopedics, The First Affiliated Hospital of Soochow University, Medical College, Soochow University, Suzhou, Jiangsu 215007, PR China.
Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, PR China.
Mater Sci Eng C Mater Biol Appl. 2020 Oct;115:111048. doi: 10.1016/j.msec.2020.111048. Epub 2020 May 7.
Drug release synchronized with tissue motion is attractive to cutaneous or musculoskeletal tissue injury repair. Here, we have developed a method of regulating drug release by mechanical on-off gates for potential treatment of repeated injury in these tissues. The mechanical gates consisted of a multilayer structure: A brittle outmost layer adhered to an elastic middle layer, which wrapped an inmost drug carrier to form the composite multilayer structure. When it was stretched, cracks appeared as mechanical gates due to mechanical performance difference between the outmost layer and the middle layer, leading to the drug release. When the external force disappeared, it recovered to stop the drug release. The controlled drug release would therefore be achieved by changing the status (opening or closure) of mechanical gates through applying this on-off mechanical stretching. A prototype based on the composite multilayer structure of adhesive coating and electrospinning technique realized the controlled release of drug and effectively repaired the incision. More types of composite multilayer structures for mechanical drug release were expected to meet curing requirement in cutaneous or musculoskeletal tissues.
药物释放与组织运动同步对于皮肤或肌肉骨骼组织损伤修复具有吸引力。在这里，我们开发了一种通过机械开关门来调节药物释放的方法，用于潜在治疗这些组织中的重复损伤。机械门由多层结构组成：最外层易碎，中间层弹性，最内层包裹药物载体，形成复合多层结构。当它被拉伸时，由于最外层和中间层之间的机械性能差异，会出现裂缝作为机械门，导致药物释放。当外力消失时，它会恢复原状以停止药物释放。通过施加这种开-关机械拉伸来改变机械门的状态（打开或关闭），就可以实现药物的控制释放。基于粘性涂层和静电纺丝技术的复合多层结构原型实现了药物的控制释放，并有效地修复了切口。预计更多类型的机械药物释放复合多层结构将满足皮肤或肌肉骨骼组织的愈合要求。
