Barragan A A, Hovingh E, Bas S, Lakritz J, Byler L, Ludwikowski A, Takitch S, Zug J, Hann S
Department of Veterinary and Biomedical Sciences, Penn State University, University Park 16802.
Department of Veterinary and Biomedical Sciences, Penn State University, University Park 16802.
J Dairy Sci. 2020 Sep;103(9):8443-8452. doi: 10.3168/jds.2019-17966. Epub 2020 Jun 26.
The transition period is one of the most challenging times for dairy cattle. Previous research suggests that treatment of postpartum cows with anti-inflammatory drugs may decrease pain and inflammation, enhancing cow welfare and performance during this challenging period. However, these strategies involve numerous time-consuming interventions, which require extra labor and do not fit modern farm logistics. The objective of this experiment was to assess the effects of acetylsalicylic acid (ASA) every 24 h for 2 d after calving on (1) daily milk yield, daily milk conductivity, and daily rumination during the first 60 days in milk (DIM), and 305-d mature-equivalent milk, milk fat, and milk protein yields, (2) body condition score, β-hydroxybutyrate (BHB), and haptoglobin, and (3) incidence of clinical diseases during the first 60 DIM. Dairy cows (n = 246) from a dairy farm located in Pennsylvania were enrolled in this experiment. Cows were blocked by parity and assigned randomly to 1 of 2 treatments: (1) ASA (n = 121), in which cows received 2 treatments with ASA (200 mg/kg; 4 boluses), the first within 12 h after parturition and the second 24 h later; or (2) untreated (UNT; n = 125), in which cows remained untreated. Blood samples were collected at 30 ± 6 h, 7 ± 3 d, and 14 ± 3 d after calving to measure BHB and haptoglobin concentrations. Body condition score was assessed at enrollment, 7 ± 3 DIM, 14 ± 3 DIM, and 50 ± 10 DIM. Furthermore, incidences of diseases, daily rumination, daily milk yield, and daily milk conductivity during the first 60 DIM and 305-d mature-equivalent milk, milk fat, and milk protein yields were collected from on-farm computer records. The data were analyzed using mixed multiple linear and logistic regression models as a randomized complete block design. Multiparous cows treated with ASA produced 1.64 kg/d more milk compared with multiparous cows that remained untreated (ASA = 41.66 ± 0.88 kg/d; UNT = 40.02 ± 0.81 kg/d) during the first 60 DIM. There was no difference in daily milk conductivity and rumination between treatments. Cows treated with ASA had lower concentration of BHB (ASA = 1.16 ± 0.64 mmol/L; UNT = 1.23 ± 0.80 mmol/L) during the first 14 ± 3 DIM and had higher body condition score within the first 50 ± 10 DIM compared with cows that remained UNT. There were no differences in circulating concentrations of haptoglobin between treatments. These results support previous findings showing that the use of anti-inflammatory drugs after calving may increase milk production and affect the metabolic status of dairy cows.
过渡期是奶牛最具挑战性的时期之一。先前的研究表明，给产后奶牛使用抗炎药物可能会减轻疼痛和炎症，在这个具有挑战性的时期提高奶牛福利和生产性能。然而，这些策略涉及大量耗时的干预措施，需要额外的劳动力，并且不符合现代农场的物流安排。本实验的目的是评估产犊后每24小时使用乙酰水杨酸（ASA）连续2天对以下方面的影响：（1）产奶后前60天的日产奶量、日乳电导率和日反刍时间，以及305天成熟当量乳、乳脂和乳蛋白产量；（2）体况评分、β-羟丁酸（BHB）和触珠蛋白；（3）产奶后前60天临床疾病的发病率。来自宾夕法尼亚州一个奶牛场的246头奶牛参与了本实验。奶牛按胎次进行分组，并随机分配到2种处理方式中的1种：（1）ASA组（n = 121），奶牛接受2次ASA处理（200 mg/kg；4次大剂量给药），第一次在产后12小时内，第二次在24小时后；或（2）未处理组（UNT；n = 125），奶牛不进行处理。在产犊后30±6小时、7±3天和14±3天采集血样，测定BHB和触珠蛋白浓度。在入组时、7±3天、14±3天和50±10天评估体况评分。此外，从农场计算机记录中收集产奶后前60天的疾病发病率、日反刍时间、日产奶量和日乳电导率，以及305天成熟当量乳、乳脂和乳蛋白产量。数据采用混合多元线性和逻辑回归模型进行分析，作为随机完全区组设计。在产奶后前60天，与未处理的经产奶牛相比，接受ASA处理的经产奶牛日产奶量多1.64 kg/d（ASA组 = 41.66±0.88 kg/d；UNT组 = 40.02±0.81 kg/d）。处理组之间的日乳电导率和反刍时间没有差异。在产犊后前14±3天，接受ASA处理的奶牛BHB浓度较低（ASA组 = 1.16±0.64 mmol/L；UNT组 = 1.23±0.80 mmol/L），与未处理的奶牛相比，在产犊后前50±10天体况评分更高。处理组之间触珠蛋白的循环浓度没有差异。这些结果支持了先前的研究发现，即产犊后使用抗炎药物可能会增加产奶量并影响奶牛的代谢状态。
