Dale J, Myhre E, Storstein O, Stormorken H, Efskind L
Am Heart J. 1977 Jul;94(1):101-11. doi: 10.1016/s0002-8703(77)80351-7.
Prevention of arterial thromboembolism with acetylsalicylic acid (ASA) was studied in 148 patients with single Starr-Edwards aortic ball-valve prostheses. These patients are suitable for such a study because they have a high incidence of arterial emboli derived mainly from thrombi formed on the valves. They were given either 1 Gm. of ASA daily or placebo in combination with anticoagulants, and were observed for 2 years. Only two emboli occurred in patients receiving ASA, none of them severe. In the placebo group 12 thromboembolic episodes were diagnosed in 10 patients, and three with cerebral emboli died; in one a subdural hematoma unrelated to the embolus was found. In addition, one fatal and the one nonfatal intracranial bleeding occurred in each group, whereas gastrointestinal complications were seen more frequently in patients taking ASA. It is concluded that ASA combined with anticoagulants offered a significantly better protection against arterial thromboembolism than did anticoagulant therapy alone.
对148例植入单个斯塔尔-爱德华兹主动脉球瓣假体的患者进行了乙酰水杨酸（ASA）预防动脉血栓栓塞的研究。这些患者适合进行此类研究，因为他们主要源于瓣膜上形成的血栓的动脉栓塞发生率很高。他们被给予每日1克ASA或安慰剂加抗凝剂，并观察2年。接受ASA的患者仅发生两例栓塞，均不严重。在安慰剂组中，10例患者诊断出12次血栓栓塞事件，3例脑栓塞患者死亡；其中1例发现与栓塞无关的硬膜下血肿。此外，每组各发生1例致命和1例非致命性颅内出血，而服用ASA的患者胃肠道并发症更常见。得出的结论是，与单独的抗凝治疗相比，ASA联合抗凝剂对动脉血栓栓塞的预防效果明显更好。
