Iida H, Kanno I, Takahashi A, Miura S, Murakami M, Takahashi K, Ono Y, Shishido F, Inugami A, Tomura N
Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels-AKITA, Japan.
Circulation. 1988 Jul;78(1):104-15. doi: 10.1161/01.cir.78.1.104.
An in vivo technique was developed for measuring the absolute myocardial blood flow with H215O and dynamic positron-emission tomography. This technique was based on a new model involving the concept of the tissue fraction, which was defined as the fraction of the tissue mass in the volume of the region of interest. The myocardium was imaged dynamically by positron-emission tomography, starting at the time of intravenous bolus injection of H215O. The arterial input function was measured continuously with a beta-ray detector. A separate image after C15O inhalation was also obtained for correction of the H215O radioactivity in the blood. The absolute myocardial blood flow and the tissue fraction were calculated for 15 subjects with a kinetic technique under region-of-interest analysis. These results seem consistent with their coronary angiographic findings. The mean value of the measured absolute myocardial blood flows in normal subjects was 0.95 +/- 0.09 ml/min/g. This technique detected a diffuse decrease of myocardial blood flow in patients with triple-vessel disease.
一种利用(H_2^{15}O)和动态正电子发射断层扫描测量绝对心肌血流量的体内技术被开发出来。该技术基于一个涉及组织分数概念的新模型，组织分数被定义为感兴趣区域体积内组织质量的分数。从静脉推注(H_2^{15}O)之时起，通过正电子发射断层扫描对心肌进行动态成像。用β射线探测器连续测量动脉输入函数。吸入(C^{15}O)后还获得了一幅单独的图像，用于校正血液中(H_2^{15}O)的放射性。采用感兴趣区域分析下的动力学技术，为15名受试者计算了绝对心肌血流量和组织分数。这些结果似乎与他们的冠状动脉造影结果一致。正常受试者测量的绝对心肌血流量的平均值为(0.95±0.09)毫升/分钟/克。该技术检测到三支血管疾病患者心肌血流量的弥漫性降低。
