Huang Zhengfei, Wang Zhifeng, Yin Kaifeng, Li Chuanhua, Guo Meihua, Lan Jing
Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School of Stomatology, Shandong University, Jinan, Shandong Province, China.
Department of Prosthodontics, School of Stomatology, Shandong University, Jinan, Shandong Province, China.
J Adv Prosthodont. 2020 Jun;12(3):157-166. doi: 10.4047/jap.2020.12.3.157. Epub 2020 Jun 18.
The aim of this study was to evaluate the clinical performance and reliability of plasma sprayed nanostructured zirconia (NSZ) coating.
This study consisted of three areas of analysis: (1) Mechanical property: surface roughness of NSZ coating and bond strength between NSZ coating and titanium specimens were measured, and the microstructure of bonding interface was also observed by scanning election microscope (SEM). (2) Biocompatibility: hemolysis tests, cell proliferation tests, and rat subcutaneous implant test were conducted to evaluate the biocompatibility of NSZ coating. (3) Mechanical compatibility: fracture and artificial aging tests were performed to measure the mechanical compatibility of NSZ-coated titanium abutments.
In the mechanical study, 400 µm thick NSZ coatings had the highest bond strength (71.22 ± 1.02 MPa), and a compact transition layer could be observed. In addition, NSZ coating showed excellent biocompatibility in both hemolysis tests and cell proliferation tests. In subcutaneous implant test, NSZ-coated plates showed similar inflammation elimination and fibrous tissue formation processes with that of titanium specimens. Regarding fatigue tests, all NSZ-coated abutments survived in the five-year fatigue test and showed sufficient fracture strength (407.65-663.7 N) for incisor teeth.
In this study, the plasma-sprayed NSZ-coated titanium abutments presented sufficient fracture strength and biocompatibility, and it was demonstrated that plasma spray was a reliable method to prepare high-quality zirconia coating.
本研究旨在评估等离子喷涂纳米结构氧化锆（NSZ）涂层的临床性能和可靠性。
本研究包括三个分析领域：（1）力学性能：测量NSZ涂层的表面粗糙度以及NSZ涂层与钛试件之间的结合强度，并通过扫描电子显微镜（SEM）观察结合界面的微观结构。（2）生物相容性：进行溶血试验、细胞增殖试验和大鼠皮下植入试验，以评估NSZ涂层的生物相容性。（3）力学相容性：进行断裂和人工老化试验，以测量NSZ涂层钛基台的力学相容性。
在力学研究中，400μm厚的NSZ涂层具有最高的结合强度（71.22±1.02MPa），并且可以观察到一个致密的过渡层。此外，NSZ涂层在溶血试验和细胞增殖试验中均表现出优异的生物相容性。在皮下植入试验中，NSZ涂层板与钛试件表现出相似的炎症消除和纤维组织形成过程。关于疲劳试验，所有NSZ涂层基台在五年疲劳试验中均存活下来，并且对切牙显示出足够的断裂强度（407.65 - 663.7N）。
在本研究中，等离子喷涂NSZ涂层的钛基台具有足够的断裂强度和生物相容性，并且证明等离子喷涂是制备高质量氧化锆涂层的可靠方法。
